This work was presented as an oral abstract at the 2010 ACVIM Forum, Anaheim, California.
Idiopathic Immune-Mediated Thrombocytopenia and Recent Vaccination in Dogs
Article first published online: 13 DEC 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 1, pages 142–148, January-February 2012
How to Cite
Huang, A.A., Moore, G.E. and Scott-Moncrieff, J.C. (2012), Idiopathic Immune-Mediated Thrombocytopenia and Recent Vaccination in Dogs. Journal of Veterinary Internal Medicine, 26: 142–148. doi: 10.1111/j.1939-1676.2011.00850.x
- Issue published online: 10 JAN 2012
- Article first published online: 13 DEC 2011
- Manuscript Accepted: 4 NOV 2011
- Manuscript Revised: 3 SEP 2011
- Manuscript Received: 29 SEP 2010
- Adverse reaction;
- Platelet recovery time;
Vaccination is often cited as a potential cause of immune-mediated thrombocytopenia (ITP) in dogs. Although an association has been documented in humans, particularly in children, this relationship has not been definitively established in dogs.
To identify the presence of an association between recent vaccination and ITP in dogs.
Forty-eight client-owned dogs with presumptive idiopathic ITP and 96 age-matched, client-owned dogs with non-immune-mediated disease.
Retrospective, case-control study. Dogs were identified through the Veterinary Medical Database (VMDB) and Hospital Information System at Purdue University.
The median age at presentation for dogs with ITP was 7 years (range: 2–15 years). The majority of the ITP group was comprised of mixed breed dogs (38%); no pure breed was represented by more than 3 cases. The number of dogs that were vaccinated within 42 days of diagnosis of ITP did not differ significantly (P = .361) between cases of presumptive ITP (4/48, 8%) and the control group (13/96, 14%).
Conclusions and Clinical Importance
This study failed to confirm the presence of an association between presumptive idiopathic ITP in dogs and recent vaccination; however, the possibility of an association cannot be completely ruled out based on the small sample populations and requires further investigation.