Parts of the study were presented at the 19th Annual Meeting, German Veterinary Medical Association; February 4–5, 2011; Leipzig, Germany.
Disease Progression and Treatment Response of Idiopathic Epilepsy in Australian Shepherd Dogs
Article first published online: 19 DEC 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 1, pages 116–125, January-February 2012
How to Cite
Weissl, J., Hülsmeyer, V., Brauer, C., Tipold, A., Koskinen, L.L., Kyöstilä, K., Lohi, H., Sauter-Louis, C., Wolf, M. and Fischer, A. (2012), Disease Progression and Treatment Response of Idiopathic Epilepsy in Australian Shepherd Dogs. Journal of Veterinary Internal Medicine, 26: 116–125. doi: 10.1111/j.1939-1676.2011.00853.x
- Issue published online: 10 JAN 2012
- Article first published online: 19 DEC 2011
- Manuscript Accepted: 14 NOV 2011
- Manuscript Revised: 25 SEP 2011
- Manuscript Received: 2 JUN 2011
- Academy of Finland
- Sigrid Juselius Foundation
- European Commission. Grant Numbers: FP7-LUPA, GA-201370
Idiopathic epilepsy (IE) in Australian Shepherds (ASs) occurs worldwide but there is a lack of description of the epilepsy syndrome in this breed. The ABCB1-1Δ mutation is more prevalent in ASs than in many other dog breeds.
Australian Shepherds suffer from a poorly controlled IE syndrome with prevailing severe courses. Seizure control and ABCB1-1Δ mutation might be related in this breed.
Fifty ASs diagnosed with IE and 50 unaffected ASs.
Predominant study design is a longitudinal cohort study. Pedigrees, medical records, seizure, and treatment data of ASs with IE were analyzed descriptively. Sex, color, and the ABCB1-1Δ genotype were compared between case and control groups and ASs with poorly or well-controlled seizures. Differences in survival times were assessed by logrank tests and Cox regression analysis.
Idiopathic epilepsy in ASs is dominated by moderate and severe clinical courses with the occurrence of cluster seizures and status epilepticus and a high seizure frequency. Poor seizure control and a high initial seizure frequency (≥10 seizure days/first 6 months) are associated with shorter survival times (P < .05). Poor seizure control, unrelated to the ABCB1(MDR1) genotype, is evident in 56% of epileptic ASs. Pedigree analysis suggests a genetic basis.
Conclusion and Clinical Importance
Frequent severe clinical courses, poor seizure control unrelated to the ABCB1(MDR1) genotype, and a young age at death compromise animal welfare and warrant further genetic studies to unravel the underlaying molecular mechanisms of IE and seizure control in the breed.