Clinicopathologic Features of Intracranial Central Neurocytomas in 2 Dogs
Article first published online: 10 JAN 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 1, pages 186–191, January-February 2012
How to Cite
Rossmeisl, J.H., Piñeyro, P., Sponenberg, D.P., Garman, R.H. and Jortner, B.S. (2012), Clinicopathologic Features of Intracranial Central Neurocytomas in 2 Dogs. Journal of Veterinary Internal Medicine, 26: 186–191. doi: 10.1111/j.1939-1676.2011.00862.x
- Issue published online: 10 JAN 2012
- Article first published online: 10 JAN 2012
- Manuscript Accepted: 23 NOV 2011
- Manuscript Revised: 28 OCT 2011
- Manuscript Received: 3 OCT 2011
- Roeder Brain Tumor Research Fund
- Brain tumor;
- CNS disorders;
In humans, central neurocytomas are rare and typically benign intracranial tumors found within the lateral ventricles, although extraventricular variants have been reported. Intracranial central neurocytomas have not been previously recognized in domestic animals.
To describe the clinicopathologic features of canine intracranial central neurocytomas.
Two dogs with spontaneous intracranial and intraventricular neoplasms.
Both dogs experienced seizures, rapid neurological deterioration, and death from tumor-associated complications within 5 days of the onset of clinical signs, and had neoplastic masses within the lateral ventricles. A brain MRI was performed in 1 dog, which revealed a T1-isointense, heterogeneously T2 and FLAIR hyperintense, and markedly and heterogeneously contrast-enhancing mass lesions within both lateral ventricles. Histologically, the neoplasms resembled oligodendrogliomas. The diagnosis of central neurocytoma was supported by documenting expression of multiple neuronal markers, including neuron-specific enolase, synaptophysin, neural-cell adhesion molecule, and neuronal nuclear antigen within the tumors, and ultrastructural evidence of neuronal differentiation of neoplastic cells.
Conclusions and Clinical Importance
Central neurocytoma should be a differential diagnosis for dogs with intraventricular brain masses. Morphologic differentiation of central neurocytoma from other intraventricular neoplasms, such as ependymoma or oligdendroglioma, can be difficult, and definitive diagnosis often requires immunohistochemical or ultrastructural confirmation of the neural origin of the neoplasm.