This work was performed at Texas A&M University. Abstract presented at Veterinary Cancer Society Annual Meeting 2009.
Safety of Masitinib Mesylate in Healthy Cats
Article first published online: 11 FEB 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 2, pages 297–302, March/April 2011
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How to Cite
Daly, M., Sheppard, S., Cohen, N., Nabity, M., Moussy, A., Hermine, O. and Wilson, H. (2011), Safety of Masitinib Mesylate in Healthy Cats. Journal of Veterinary Internal Medicine, 25: 297–302. doi: 10.1111/j.1939-1676.2011.0687.x
- Issue published online: 7 MAR 2011
- Article first published online: 11 FEB 2011
- Submitted August 31, 2010; Revised December 7, 2010; Accepted December 22, 2010.
- Receptor tyrosine kinase inhibitor
Background: Masitinib mesylate is a PO-administered tyrosine kinase inhibitor developed both for human and animal diseases with activity against both mutated and wild type forms of the c-kit receptor and platelet-derived growth factor receptors α and β, and is currently registered in Europe for the treatment of mast cell tumors in dogs.
Hypothesis/Objectives: The objective of this study was to determine if healthy cats can tolerate administration of masitinib without clinically relevant adverse effects.
Animals: Twenty healthy research colony-specific pathogen-free cats.
Methods: This study was a prospective, randomized phase 1 clinical trial. Masitinib was administered PO to 20 healthy cats. Ten cats received 50 mg masitinib every other day for 4 weeks, and 10 cats received 50 mg masitinib daily for 4 weeks.
Results: Clinically relevant proteinuria was noted in 2/20 (10%) cats (both treated daily), and neutropenia was noted in 3/20 (15%) (seen in both treatment groups). An increase in serum creatinine concentration and adverse gastrointestinal effects were noted in some cats.
Conclusions and Clinical Importance: Masitinib mesylate was tolerated in the majority of cats. Long-term administration and pharmacokinetic studies are needed to further assess the use of masitinib in cats.