• 1
    Atkins CE, Gallo AM, Kurzman ID, Cowen P. Risk factors, clinical signs, and survival in cats with a clinical diagnosis of idiopathic hypertrophic cardiomyopathy: 74 cases (1985–1989). J Am Vet Med Assoc 1992;201:613618.
  • 2
    Rush JE, Freeman LM, Fenollosa NK, Brown DJ. Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990–1999). J Am Vet Med Assoc 2002;220:202207.
  • 3
    Schober KE, Maerz I. Assessment of left atrial appendage flow velocity and its relation to spontaneous echocardiographic contrast in 89 cats with myocardial disease. J Vet Intern Med 2006;20:120130.
  • 4
    Dilsizian V, Bonow RO, Epstein SE, Fananapazir L. Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 1993;22:796804.
  • 5
    Ommen SR, Nishimura RA. Hypertrophic cardiomyopathy. Curr Probl Cardiol 2004;29:239291.
  • 6
    Bright JM, Golden AL. Evidence for or against the efficacy of calcium channel blockers for management of hypertrophic cardiomyopathy in cats. Vet Clin North Am Small Anim Pract 1991;21:10231034.
  • 7
    Bright JM, Golden AL, Gompf RE, et al. Evaluation of the calcium channel-blocking agents diltiazem and verapamil for treatment of feline hypertrophic cardiomyopathy. J Vet Intern Med 1991;5:272282.
  • 8
    Fox PR. Evidence for or against efficacy of beta-blockers and aspirin for management of feline cardiomyopathies. Vet Clin North Am Small Anim Pract 1991;21:10111022.
  • 9
    Berdeaux A. Preclinical results with I(f) current inhibition by ivabradine. Drugs 2007;67 (Suppl 2):2533.
  • 10
    Savelieva I, Camm AJ. If inhibition with ivabradine: Electrophysiological effects and safety. Drug Saf 2008;31:95107.
  • 11
    Simon L, Ghaleh B, Puybasset L, et al. Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. J Pharmacol Exp Ther 1995;275:659666.
  • 12
    Colin P, Ghaleh B, Monnet X, et al. Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs. J Pharmacol Exp Ther 2004;308:236240.
  • 13
    Macgregor JM, Rush JE, Rozanski EA, et al. Comparison of pharmacodynamic variables following oral versus transdermal administration of atenolol to healthy cats. Am J Vet Res 2008;69:3944.
  • 14
    Wilkinson PL, Tyberg JV, Moyers JR, White AE. Correlates of myocardial oxygen consumption when afterload changes during halothane anesthesia in dogs. Anesth Analg 1980;59:233239.
  • 15
    Schober KE, Fuentes VL, Bonagura JD. Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats. Am J Vet Res 2003;64:93103.
  • 16
    Schober KE, Maerz I. Doppler echocardiographic assessment of left atrial appendage flow velocities in normal cats. J Vet Cardiol 2005;7:1525.
  • 17
    Thomas WP, Gaber CE, Jacobs GJ, et al. Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Echocardiography Committee of the Specialty of Cardiology, American College of Veterinary Internal Medicine. J Vet Intern Med 1993;7:247252.
  • 18
    Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358367.
  • 19
    Koffas H, Dukes-McEwan J, Corcoran BM, et al. Pulsed tissue Doppler imaging in normal cats and cats with hypertrophic cardiomyopathy. J Vet Intern Med 2006;20:6577.
  • 20
    Chetboul V, Serres F, Gouni V, et al. Radial strain and strain rate by two-dimensional speckle tracking echocardiography and the tissue velocity based technique in the dog. J Vet Cardiol 2007; 9:6981.
  • 21
    Chetboul V, Athanassiadis N, Carlos C, et al. Quantification, repeatability, and reproducibility of feline radial and longitudinal left ventricular velocities by tissue Doppler imaging. Am J Vet Res 2004; 65:566572.
  • 22
    Chetboul V, Concordet D, Pouchelon JL, et al. Effects of inter- and intra-observer variability on echocardiographic measurements in awake cats. J Vet Med A Physiol Pathol Clin Med 2003;50:326331.
  • 23
    Chetboul V, Sampedrano CC, Tissier R, et al. Reference range values of regional left ventricular myocardial velocities and time intervals assessed by tissue Doppler imaging in young nonsedated maine coon cats. Am J Vet Res 2005;66:19361942.
  • 24
    Disatian S, Bright JM, Boon J. Association of age and heart rate with pulsed-wave Doppler measurements in healthy, nonsedated cats. J Vet Intern Med 2008;22:351356.
  • 25
    Food and Drug Administration, HHS. International Conference on Harmonisation. Choice of control group and related issues in clinical trials; availability notice. Fed Regist 2001;66:2439024391.
  • 26
    Kaul S, Diamond GA. Good enough: A primer on the analysis and interpretation of noninferiority trials. Ann Intern Med 2006;145:6269.
  • 27
    Rothmann M, Li N, Chen G, et al. Design and analysis of non-inferiority mortality trials in oncology. Stat Med 2003;22:239264.
  • 28
    Vilaine JP. The discovery of the selective I(f) current inhibitor ivabradine. A new therapeutic approach to ischemic heart disease. Pharmacol Res 2006;53:424434.
  • 29
    Fox PR. Hypertrophic cardiomyopathy. Clinical and pathologic correlates. J Vet Cardiol 2003;5:3945.
  • 30
    Baicu CF, Zile MR, Aurigemma GP, Gaasch WH. Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. Circulation 2005;111:23062312.
  • 31
    Simpson KE, Devine BC, Gunn-Moore DA, et al. Assessment of the repeatability of feline echocardiography using conventional echocardiography and spectral pulse-wave Doppler tissue imaging techniques. Vet Radiol Ultrasound 2007;48:5868.
  • 32
    Carlos Sampedrano C, Chetboul V, Gouni V, et al. Systolic and diastolic myocardial dysfunction in cats with hypertrophic cardiomyopathy or systemic hypertension. J Vet Intern Med 2006;20: 11061115.
  • 33
    Myreng Y, Smiseth OA. Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation. Circulation 1990;81:260266.
  • 34
    Smith SA, Tobias AH, Jacob KA, et al. Arterial thromboembolism in cats: Acute crisis in 127 cases (1992–2001) and long-term management with low-dose aspirin in 24 cases. J Vet Intern Med 2003;17:7383.
  • 35
    Sanada H, Shimizu M, Shimizu K, et al. Left atrial afterload mismatch in hypertrophic cardiomyopathy. Am J Cardiol 1991;68:10491054.
  • 36
    Schober KE, Bonagura JD, Luis-Fuentes V. Atenolol versus diltiazem for LV diastolic function in cats with occult hypertrophic cardiomyopathy. Proceedings, Annual Forum of ACVIM, 2007, Seattle, WA.
  • 37
    Bilge M, Guler N, Eryonucu B, Erkoc R. Does acute-phase beta blockade reduce left atrial appendage function in patients with chronic nonvalvular atrial fibrillation? J Am Soc Echocardiogr 2001;14:194199.
  • 38
    Kamiyama N, Koyama Y, Suetsuna R, et al. Decreased left atrial appendage flow velocity with atrial fibrillation caused by negative inotropic agents: Report of two cases. Circ J 2003;67:277278.
  • 39
    Oki T, Iuchi A, Tabata T, et al. Transesophageal pulsed Doppler echocardiographic evaluation of left atrial systolic performance in hypertrophic cardiomyopathy: Combined analysis of transmitral and pulmonary venous flow velocities. Clin Cardiol 1997;20:4754.