Coagulation Profiles of Healthy Andalusian Donkeys are Different than Those of Healthy Horses
Article first published online: 7 JUL 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 4, pages 967–970, July/August 2011
How to Cite
Mendoza, F.J., Perez-Ecija, R.A., Monreal, L. and Estepa, J.C. (2011), Coagulation Profiles of Healthy Andalusian Donkeys are Different than Those of Healthy Horses. Journal of Veterinary Internal Medicine, 25: 967–970. doi: 10.1111/j.1939-1676.2011.0748.x
- Issue published online: 20 JUL 2011
- Article first published online: 7 JUL 2011
- Submitted January 13, 2011; Revised April 26, 2011; Accepted May 5, 2011.
- Clotting times;
- Fibrinogen degradation products
Background: Coagulation disorders are frequently diagnosed, especially in hospitalized equidae, and result in increased morbidity and mortality. However, hemostatic reference intervals have not been established for donkeys yet.
Objectives: To determine whether the most common coagulation parameters used in equine practice are different between healthy donkeys and horses.
Animals: Thirty-eight healthy donkeys and 29 healthy horses.
Methods: Blood samples were collected to assess both coagulation and fibrinolytic systems by determination of platelet count, fibrinogen concentration, clotting times (prothrombin time [PT] and activated partial thromboplastin time [aPTT]), fibrin degradation products (FDP) and D-Dimer concentrations.
Results: PT and aPTT in donkeys were significantly (P < .05) shorter than those of horses. In contrast, FDP and D-Dimer concentrations were significantly (P < .05) higher in donkeys than in horses.
Conclusions and Clinical Importance: The coagulation parameters most commonly determined in equine practice are different in donkeys compared with horses. Thus, the use of normal reference ranges reported previously for healthy horses in donkeys might lead to a misdiagnosis of coagulopathy in healthy donkeys, and unnecessary treatments in sick donkeys. This is the first report of normal coagulation profile results in donkeys, and further studies are warranted to elucidate the physiological mechanisms of the differences observed between donkeys and horses.