This work was conducted at the Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen. Parts of this study have been presented at the 2010 ACVIM Forum, Anaheim, CA.
Prevalence of Hypertrophic Cardiomyopathy in a Cohort of British Shorthair Cats in Denmark
Article first published online: 7 JUL 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 4, pages 866–871, July/August 2011
How to Cite
Granström, S., Nyberg Godiksen, M.T., Christiansen, M., Pipper, C.B., Willesen, J.T. and Koch, J. (2011), Prevalence of Hypertrophic Cardiomyopathy in a Cohort of British Shorthair Cats in Denmark. Journal of Veterinary Internal Medicine, 25: 866–871. doi: 10.1111/j.1939-1676.2011.0751.x
- Issue published online: 20 JUL 2011
- Article first published online: 7 JUL 2011
- Submitted February 17, 2011; Revised April 19, 2011; Accepted May 12, 2011.
Vol. 25, Issue 5, 1194, Article first published online: 20 SEP 2011
Background: Familial hypertrophic cardiomyopathy (HCM) has been described previously in British Shorthair cats (BSH), but until now, no reports have been published describing the prevalence of the disease within this breed.
Objectives: The aim of this study was to assess the prevalence of HCM in a large cohort of BSH and to evaluate the effect of sex, weight, and increasing age as potential risk factors for this disease.
Animals: Three hundred and twenty-nine BSH presented for routine HCM screening during a 4-year period.
Methods: Prospective cross-sectional study in which all cats were screened for HCM by conventional echocardiography.
Results: A total of 329 cats were examined, 214 females and 115 males, with a median age of 2.3 years (range, 0.8–14.1). Twenty-eight cats (8.5%) were classified as HCM-positive, 14 (4.3%) as equivocal, 282 (85.7%) as HCM-negative, and 5 (2.1%) were diagnosed with other cardiac diseases. The median age for diagnosis of HCM was 2.7 years (range, 0.9–14.1). Male cats had a significantly higher occurrence of HCM (20.4%) compared with the females (2.1%) corresponding to an odds ratio of 7.89 (95 % CI, 2.54–28.08) for males versus females adjusted for age and weight (P < .001).
Conclusion: The BSH in our cohort had a high prevalence of HCM, often of early onset and with a significant male sex predisposition. We strongly recommend echocardiographic screening in this breed, especially cats used for breeding.