Preliminary results from this study were presented at the 9th Congress of the European Veterinary Emergency and Critical Care Society (EVECCS), in Cambridge, UK, June 2010. The manuscript represents a portion of a thesis submitted by the first author at the Universitat Autònoma de Barcelona as partial fulfilment of the requirements for her PhD program, supervised by the last authors.
Synovial Fluid D-Dimer Concentration in Foals with Septic Joint Disease
Article first published online: 22 JUL 2011
Copyright © 2011 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 25, Issue 5, pages 1113–1117, September/October 2011
How to Cite
Ribera, T., Monreal, L., Armengou, L., Ríos, J. and Prades, M. (2011), Synovial Fluid D-Dimer Concentration in Foals with Septic Joint Disease. Journal of Veterinary Internal Medicine, 25: 1113–1117. doi: 10.1111/j.1939-1676.2011.0758.x
- Issue published online: 20 SEP 2011
- Article first published online: 22 JUL 2011
- Submitted October 8, 2010; Revised April 18, 2011; Accepted June 1, 2011.
- Equine foals;
- Septic arthritis;
- Synovial fibrinolysis
Background: Increased synovial fibrinolytic activity (detected by increases in synovial D-Dimer concentrations) has been observed in different joint diseases in humans and adult horses, presumably in order to minimize fibrin deposition within the joint and thus avoid its detrimental effects.
Objective: To investigate fibrinolytic pathway activation in joint sepsis in foals by measuring synovial D-Dimer concentrations.
Animals: Eighteen septic foals with septic joints, 9 septic foals without septic joints, 9 systemically healthy foals with septic joint, and 3 controls are included.
Methods: Prospective observational clinical study of foals admitted for septic arthritis. Synovial D-Dimer concentration and routine synovial fluid analysis were performed. Diagnosis of joint sepsis was made whenever synovial total nucleated cell count was >30,000 cells/μL, synovial total protein >4 g/dL, and neutrophil percentage of >80%, or synovial fluid culture resulted positive. Results were compared among groups by general lineal models.
Results: Synovial D-Dimer concentration was significantly (P < .001) higher in the foals with septic joints compared with foals without joint disease (P < .001).
Conclusions and Clinical Importance: Septic joint disease is associated with a marked increase of synovial D-Dimer concentration (marked activation of the fibrinolytic activity) within the affected joint. Although further studies are needed, the measurement of synovial D-Dimer concentration may be considered a complementary diagnostic marker of septic joint disease.