• Open Access

Echocardiographic and Tissue Doppler Imaging Alterations Associated with Spontaneous Canine Systemic Hypertension

Authors

  • C. Misbach,

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • V. Gouni,

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • R. Tissier,

    1. UMR INSERM U955, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    2. Unité de Pharmacie-Toxicologie, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • E. Trehiou-Sechi,

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • A.M.P. Petit,

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • C. Carlos Sampedrano,

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • J-L. Pouchelon,

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    2. UMR INSERM U955, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author
  • V. Chetboul

    1. Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    2. UMR INSERM U955, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort cedex, France
    Search for more papers by this author

  • Some of these results were presented as a short communication at the ECVIM congress in Toulouse, September 2010.

Corresponding author: V. Chetboul, DVM, PhD, Dipl-ECVIM-CA (Cardiology), Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), Ecole Nationale Vétérinaire d'Alfort, 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France; e-mail: vchetboul@vet-alfort.fr

Abstract

Background: Feline systemic arterial hypertension (SHT) is associated with a wide spectrum of left ventricular (LV) geometric patterns as well as diastolic, and to a lesser extent, systolic myocardial dysfunction. However, little is known about SHT-related cardiac changes in dogs.

Hypothesis: SHT in dogs is responsible for morphological and functional cardiac alterations.

Animals: Thirty dogs with spontaneous untreated SHT and 28 age- and body weight-matched healthy dogs as controls.

Methods: Prospective observational study. Conventional echocardiography and 2-dimensional color tissue Doppler imaging were performed in SHT dogs by trained observers and compared with controls.

Results: Forty-seven percent of SHT dogs (14/30) had diffuse concentric hypertrophy. None had left atrial dilatation and 10/30 (33%) had aortic insufficiency (AoI) associated with proximal aortic dilatation. Longitudinal diastolic left ventricular free wall (LVFW) motion was altered in all SHT dogs at the base (early to late diastolic wave ratio, E/A = 0.5 ± 0.1 versus 1.3 ± 0.3 for controls, P < .0001) and the apex (E/A = 1.6 ± 1.7 versus 3.9 ± 3.1, P < .05). Longitudinal motion of the interventricular septum at the base (E/A = 0.7 ± 0.4 versus 1.1 ± 0.1, P < .01) and radial LVFW motion in the subendocardium (E/A = 0.9 ± 0.5 versus 1.6 ± 0.3, P < .01) were also altered in dogs with SHT. Longitudinal LVFW systolic velocities and gradients were also significantly decreased (P < .05) in SHT dogs.

Conclusion and Clinical Importance: As in SHT in cats, SHT in dogs is associated with myocardial dysfunction independently of the presence of myocardial hypertrophy. However, unlike feline SHT, it results in a homogeneous LV geometric pattern with a relatively high prevalence of AoI.

Ancillary