With the exception of histological evaluation, all work was performed at Texas A&M University. Histological evaluation was performed at North Carolina State University.
Urinary Biomarkers of Renal Disease in Dogs with X-Linked Hereditary Nephropathy
Article first published online: 22 FEB 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 2, pages 282–293, March-April 2012
How to Cite
Nabity, M.B., Lees, G.E., Cianciolo, R., Boggess, M.M., Steiner, J.M. and Suchodolski, J.S. (2012), Urinary Biomarkers of Renal Disease in Dogs with X-Linked Hereditary Nephropathy. Journal of Veterinary Internal Medicine, 26: 282–293. doi: 10.1111/j.1939-1676.2012.00891.x
Presented in part at the 2009 ACVIM Forum, Montreal, Canada, June 2009, at the 45th Annual Meeting of the American Society for Veterinary Clinical Pathology, Baltimore, MD, on October 31, 2010, and at the International Society of Nephrology Forefronts Symposium, Aarhus, Denmark, on September 22–25, 2011.
- Issue published online: 20 MAR 2012
- Article first published online: 22 FEB 2012
- Manuscript Accepted: 9 JAN 2012
- Manuscript Revised: 1 NOV 2011
- Manuscript Received: 25 AUG 2011
- Morris Animal Foundation. Grant Number: C07-311
- National Institutes of Health. Grant Numbers: DK57676, DK64273
|jvim891-sup-0001-FigS1.pdf||application/PDF||402K||Fig S1. Plot of urinary NAG activity during storage at room temperature over 24 hours. A minimal but statistically significant decrease in NAG activity was observed after 12–24 hours for 2 samples (represented by the orange and green lines).|
|jvim891-sup-0002-FigS2.pdf||image/eps||402K||Fig S2. Plots of urinary NAG activity during storage at 4, −20, and −80°C over 1 year. A statistically significant, but not clinically significant, increase in NAG activity was observed for 2 of the samples stored at 4°C (represented by the green and blue lines). There was no statistical evidence of an effect of storage temperature on NAG activity for 1 year at −20 or −80°C.|
|jvim891-sup-0003-FigS3.pdf||image/eps||402K||Fig S3. Plot of urinary NAG activity and NGAL concentration over 0–5 and 0–4 freeze-thaw cycles, respectively. There was a statistically significant (P = .05) but clinically insignificant increase in NAG activity after 4 freeze-thaw cycles. The NGAL concentration was not significantly affected with up to 4 freeze-thaw cycles.|
|jvim891-sup-0004-FigS4.pdf||image/eps||407K||Fig S4. Descriptive plots (median, range) and linear regression plots (mean [B2M, NGAL, NAG, IgG] or median [RBP], confidence interval) for each analyte based on the year in which the urine sample was collected. Although all analytes except for NAG exhibited an increasing trend as storage time decreased, a statistically significant increase was not observed. The following P-values were obtained: uRBP/c = 0.072; uB2M = 0.065; uNGAL/c = 0.065; uNAG/c = 0.624; uIgG/c = 0.062.|
|jvim891-sup-0005-TableS1.pdf||image/eps||407K||Table S1. Correlations (Corr) of urinary biomarkers in dogs with XLHN. For all correlations P < .001.|
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