• Open Access

Comparative Echocardiographic and Clinical Features of Hypertrophic Cardiomyopathy in 5 Breeds of Cats: A Retrospective Analysis of 344 Cases (2001–2011)

Authors

  • E. Trehiou-Sechi,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
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  • R. Tissier,

    1. INSERM, U955, Equipe 03, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil cedex, France
    2. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Pharmacie-Toxicologie, 7 avenue du général de Gaulle 94704 Maisons-Alfort cedex, France
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  • V. Gouni,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
    2. INSERM, U955, Equipe 03, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil cedex, France
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  • C. Misbach,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
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  • A.M.P. Petit,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
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  • D. Balouka,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
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  • C. Carlos Sampedrano,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
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  • M. Castaignet,

    1. UCVet, Paris, France
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  • J.-L. Pouchelon,

    1. Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
    2. INSERM, U955, Equipe 03, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil cedex, France
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  • V. Chetboul

    Corresponding author
    1. INSERM, U955, Equipe 03, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil cedex, France
    • Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France
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  • Some of these results were presented as a poster at the ECVIM congress in Toulouse (France), September 2010 and as a short communication at the ECVIM congress in Sevilla (Spain), September 2011.

Corresponding author: Valérie Chetboul, DVM, PhD, Dipl-ECVIM-CA (Cardiology), Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Unité de Cardiologie d'Alfort (UCA), Centre Hospitalier Universitaire Vétérinaire d'Alfort (CHUVA), 7 avenue du général de Gaulle, 94704 Maisons-Alfort cedex, France; e-mail: vchetboul@vet-alfort.fr.

Abstract

Background

Primary hypertrophic cardiomyopathy (HCM) is the most common feline heart disease and has been demonstrated to be inherited in some breeds. However, few studies have compared HCM phenotypes and survival according to breed.

Objectives

To compare epidemiological characteristics, clinical findings, left ventricular (LV) geometric patterns, and survival in several breeds of cats with HCM.

Animals

Three hundred and forty-four cats from 5 different breeds (Persian, Domestic Shorthair [DS], Sphynx, Maine coon [MC], and Chartreux) with primary HCM diagnosed by conventional echocardiography.

Methods

Retrospective study. Cats were classified according to breed and clinical status.

Results

Age at the time of diagnosis was lower (P < .001) in MC (median age, 2.5 years) and Sphynx (3.5 years) than in other breeds (OB), ie, 8.0, 8.0, and 11.0 years for DS, Chartreux, and Persians, respectively. The prevalence of LV outflow tract obstruction was higher (P < .001) in Persians (23/41; 56%) than in OB (115/303; 38%). Age at the first cardiac event was lower (P < .01) in MC (median age, 2.5 years) than in OB (7.0 years). All cats surviving > 15 years of age were DS, Persians, or Chartreux. Sudden death (representing 24% of all cardiac deaths) was observed only in 3 breeds (DS, MC, and Sphynx).

Conclusion and Clinical Importance

As in humans, feline HCM is characterized by marked phenotypic variability with several breed-dependent features regarding epidemiology, LV geometric patterns, and clinical course (ie, age at diagnosis, 1st cardiac event, and cause of death).

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