• Open Access

Systemic Inflammation and Endothelial Dysfunction in Dogs with Congestive Heart Failure

Authors


  • Partial results of this study were presented as a Research Report at the 2010 ACVIM Forum in Anaheim, CA.

Corresponding author: Suzanne M. Cunningham, Tufts Cummings School of Veterinary Medicine, Department of Clinical Sciences, 200 Westboro Road, North Grafton, MA 01536; e-mail: suzanne.cunningham@tufts.edu.

Abstract

Background

Congestive heart failure (CHF) is associated with endothelial dysfunction in people and in dogs with experimentally induced CHF, but this is not well characterized in dogs with naturally occurring CHF.

Hypothesis/Objectives

To evaluate endothelial function via assessment of reactive hyperemia (RH) in healthy dogs and dogs with CHF, and to assess for relationships with plasma biomarkers of vascular function and clinical markers of disease severity.

Animals

Twenty client-owned animals with CHF due to myxomatous mitral valve disease (n = 15) or dilated cardiomyopathy (n = 5) and 17 healthy control dogs.

Methods

Prospective case-controlled observational study. Dogs underwent blood sampling, echocardiography, and Doppler assessment of brachial artery velocity (VTI) at baseline and during reactive hyperemia (RH-VTI). RH-VTIs between control dogs and dogs with CHF were compared, and the relationships between RH-VTI, clinical parameters, and plasma biomarkers were assessed.

Results

Dogs with CHF (96.5 ± 51.7%) had an attenuated % increase in VTI during RH compared to healthy controls (134.8 ± 58.7%; = .04). Increasing ISACHC class (R2 = 0.24; = .004), plasma NT-proBNP (R2 = 0.15; = .03) and CRP (R2 = 0.2; = .02) were associated with reduced RH-VTI. Increased plasma CRP, NOx, and NT-proBNP concentrations were found in dogs with CHF (< .02 for all). No differences were detected in other plasma markers.

Conclusions and Clinical Importance

Dogs with CHF have an attenuated RH response, and increased plasma CRP and NOx concentrations. Doppler assessment of RH velocity could represent a novel noninvasive method of evaluating endothelial function in the dog.

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