1939-1676/asset/bannerforeground.gif?v=1&s=3ab0e3dc9095388081db55dec537408d13224811)
Review
You have free access to this content
Drug Hypersensitivity Reactions Targeting the Skin in Dogs and Cats
Article first published online: 21 APR 2012
DOI: 10.1111/j.1939-1676.2012.00927.x
Copyright © 2012 by the American College of Veterinary Internal Medicine
Additional Information
How to Cite
Voie, K.L., Campbell, K.L. and Lavergne, S.N. (2012), Drug Hypersensitivity Reactions Targeting the Skin in Dogs and Cats. Journal of Veterinary Internal Medicine, 26: 863–874. doi: 10.1111/j.1939-1676.2012.00927.x
Publication History
- Issue published online: 13 JUL 2012
- Article first published online: 21 APR 2012
- Manuscript Accepted: 7 MAR 2012
- Manuscript Revised: 23 JAN 2012
- Manuscript Received: 7 NOV 2011
References
- 1
- 2Scott D, Griffin C, eds. Muller & Kirk's Small Animal Dermatology. Philadelphia, PA: WB Saunders; 2001.
- 3, . Mechanisms of drug-induced allergy. Mayo Clin Proc 2009;84:268–272.
- 4
- 5. Incidence, prevalence and the rates of cutaneous reactions to drugs. J Eur Acad Dermatol Venereol 2000;14:435.
- 6, , . Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies. J Am Med Assoc 1998;279:1200–1205.
- 7, , , et al. The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group. J Am Med Assoc 1997;277:307–311.
- 8, , , et al. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. J Am Med Assoc 1997;277:301–306.
- 9. Rates of cutaneous reactions to drugs. Arch Dermatol 2001;137:765–770.
- 10. Adverse drug reactions: Report of the Australian Veterinary Association Adverse Drug Reaction Subcommittee, 1992. Aust Vet J 1992;69:288–291.
- 11. Adverse drug reactions: Report of the Australian Veterinary Association Adverse Drug Reaction Subcommittee, 1993. Aust Vet J 1994;71:53–57.
- 12. Suspected adverse reactions to human medicines in animals. Vet Rec 2007;161:319–320.
- 13, , , . Suspected adverse reactions, 2009. Vet Rec 2010;167:118–121.
- 14, , , et al. Adverse drug event reports at the United States Food And Drug Administration Center for Veterinary Medicine. J Am Vet Med Assoc 2004;225:533–536.
- 15, , eds. Veterinary Pharmacology & Therapeutics. Ames, IA: Wiley-Blackwell; 2009.
- 16, , . Adverse drug reactions: A review of relevant factors. J Clin Pharmacol 2000;40:1093–1101.
- 17. Immune-mediated adverse drug reactions. Chem Res Toxicol 2009;22:24–34.
- 18, , . The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity. Curr Opin Allergy Clin Immunol 2008;8:299–307.
- 19. Anaphylactic reaction in a cow due to parenteral administration of penicillin-streptomycin. Can Vet J 2009;50:741–744.
- 20. Anaphylaxis and anaesthesia. Vet Anaesth Analg 2010;37:306–310.
- 21. Anaphylaxis to ophthalmic medication in a cat. J Vet Emerg Crit Care 2000;10:169–171.Direct Link:
- 22, , , et al. Pathophysiology of urticaria. Clin Rev Allergy Immunol 2006;30:3–11.
- 23. The molecular logic of pemphigus and impetigo: The desmoglein story. Vet Dermatol 2009;20:308–312.
- 24. Pemphigus autoimmunity: Hypotheses and realities. Autoimmunity 2012;45:7–35.
- 25, . Metaflumizone-amitraz (Promeris)-associated pustular acantholytic dermatitis in 22 dogs: Evidence suggests contact drug-triggered pemphigus foliaceus. Vet Dermatol 2011;22:436–448.
- 26, . Canine immune-mediated hemolytic anemia: Pathophysiology, clinical signs, and diagnosis. Compend Contin Educ Vet 2007;29:217–225.
- 27, . Recent advances in the immunopathogenesis of systemic lupus erythematosus. West J Med 1975;122:130–144.
- 28, , , et al. Adverse reactions suggestive of type III hypersensitivity in six healthy dogs given human albumin. J Am Vet Med Assoc 2007;230:873–879.
- 29, , . Systemic vasculitis with severe cutaneous manifestation as a suspected idiosyncratic hypersensitivity reaction to fenbendazole in a cat. J Vet Intern Med 2008;22:666–670.
- 30, , , . Nephrotic syndrome associated with administration of sulfadimethoxine/ormetoprim in a Dobermann. J Small Anim Pract 2005;46:232–236.
- 31, , , et al. Neutrophilic dermatitis and immune-mediated haematological disorders in a dog: Suspected adverse reaction to carprofen. J Small Anim Pract 2005;46:237–242.
- 32. Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity. Toxicology 2005;209:113–118.
- 33, , , . Association of drug-serum protein adducts and anti-drug antibodies in dogs with sulphonamide hypersensitivity: A naturally occurring model of idiosyncratic drug toxicity. Clin Exp Allergy 2006;36:907–915.
- 34. An innate sense of danger. Ann N Y Acad Sci 2002;961:341–342.
- 35
- 36, , , et al. “Danger” conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells. J Pharmacol Exp Ther 2009;331:372–381.
- 37
- 38, . A complex interaction between drug allergy and viral infection. Clin Rev Allergy Immunol 2007;33:124–133.
- 39, . Idiosyncratic cutaneous adverse drug reactions in the cat: Literature review and report of 14 cases(1990–1996). Feline Pract 1998;26:10–15.
- 40, Delayed cutaneous manifestations of drug hypersensitivity. Med Clin North Am 2010; 94: 711–725, x.
- 41, . Idiosyncratic cutaneous adverse drug reactions in the dog: Literature review and report of 101 cases (1990–1996). Canine Practice 1999;24:16–22.
- 42, , . Methimazole treatment of 262 cats with hyperthyroidism. J Vet Intern Med 1988;2:150–157.
- 43, , , et al. Efficacy and safety of once versus twice daily administration of methimazole in cats with hyperthyroidism. J Am Vet Med Assoc 2003;222:954–958.
- 44, , . Putative Rimadyl induced neutrophilic dermatosis resembling Sweet's syndrome in two dogs. Proceedings Annual Member's Meeting of the American Academy of Veterinary Dermatology 1999;15:69–70.
- 45, , , . Extracutaneous neutrophilic inflammation in a dog with lesions resembling Sweet's syndrome. Vet Dermatol 2009;20:200–205.
- 46Gross TI, Ihrke PJ, Walder EJ, Affolter VK, eds. Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis, 2 ed. Oxford: Blackwell Science Ltd, 2005.
- 47. Blistering drug eruptions in animals. Clin Dermatol 1993;11:567–574.
- 48, , . Pemphigus foliaceus-like drug reaction in a 3-month-old crossbreed dog treated for juvenile cellulitis. Vet Dermatol 2007;18:353–359.
- 49, , . Drug-induced pemphigus. I. A survey. Clin Dermatol 1993;11:501–505.
- 50, , , et al. Putative drug-related pemphigus foliaceus in four dogs. Vet Dermatol 2002;13:195–202.
- 51, . Suspected polymyxin B-induced pemphigus vulgaris in a dog. Vet Dermatol 2007;18:165–170.
- 52, , . A retrospective study of canine and feline cutaneous vasculitis. Vet Dermatol 2001;12:255–264.
- 53, . Anti-platelet antibodies in a natural animal model of sulphonamide-associated thrombocytopaenia. Platelets 2007;18:595–604.
- 54, , , et al. Cutaneous and ocular adverse reactions in a dog following meloxicam administration. Vet Dermatol 2007;18:45–49.
- 55, . Cutaneous drug eruptions with epidermal necrosis: A discussion of pathophysiologic and comparative aspects. Clin Dermatol 1994;12:525–528.
- 56, , . A case of superficial suppurative necrolytic dermatitis of miniature schnauzers with identification of a causative agent using patch testing. Vet Dermatol 2008;19:395–399.
- 57. Erythema multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis in the Dog: Clinical classification, drug exposure, and histopathologic correlations. Vet Allergy Clin Immunol 1998;6:13–20.
- 58, . Erythema multiforme in dogs and cats: Literature review and case material from the Cornell University College of Veterinary Medicine (1988–1996). Vet Dermatol 2002;10:297–309.Direct Link:
- 59. Apoptosis in selected skin diseases. Vet Dermatol 2008;9:221–229.Direct Link:
- 60, . Severe cutaneous adverse reactions: Acute generalized exanthematous pustulosis, toxic epidermal necrolysis and Stevens-Johnson syndrome. Med Clin North Am 2010;94:727–742, x.
- 61, , . Toxic epidermal necrolysis associated with flea dips. Vet Hum Toxicol 1992;34:57–61.
- 62, . Drugs and Wells' syndrome: A possible causal relationship? Int J Dermatol 2001;40:138–140.
- 63, , , . Comparison of clinical history and dermatologic findings in 29 dogs with severe eosinophilic dermatitis: A retrospective analysis. Vet Dermatol 2006;17:338–347.
- 64, , , et al. Eosinophilic dermatitis with edema in nine dogs, compared with eosinophilic cellulitis in humans. J Am Vet Med Assoc 1999;215:649–653.
- 65, , , et al. Cutaneous symptoms in drug allergy: What have we learnt? Curr Opin Allergy Clin Immunol 2009;9:431–436.
- 66, , , et al. Provocation tests in diagnosing drug hypersensitivity. Curr Pharm Des 2008;14:2792–2802.
- 67, . The complex clinical picture of beta-lactam hypersensitivity: Penicillins, cephalosporins, monobactams, carbapenems, and clavams. Med Clin North Am 2010;94:805–820, xii.
- 68, , , et al. Desensitization to co-trimoxazole (trimethoprim-sulphamethoxazole) in HIV-infected patients: Is patch testing a useful predictor of reaction? J Infect 1999;38:111–115.
- 69, . Patch testing in drug allergy. Curr Opin Allergy Clin Immunol 2010;10:291–296.
- 70. Veterinary Immunology An Introduction, 7 ed. Philadelphia: WB Saunders Company; 2008.
- 71, , , et al. Non specific interactions in anti-agent IgE-RIA to anesthetic agents. Ann Fr Anesth Reanim 1993;12:141–146.
- 72, , , et al. Immune response to sulfamethoxazole in patients with AIDS. Clin Diagn Lab Immunol 1995;2:199–204.
- 73, , , et al. Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. J Clin Invest 1990;85:1967–1973.
- 74, , , . Patients with delayed-onset sulfonamide hypersensitivity reactions have antibodies recognizing endoplasmic reticulum luminal proteins. J Pharmacol Exp Ther 1997;282:1064–1071.
- 75, , . Anti-myeloperoxidase and anti-cathepsin G antibodies in sulphonamide hypersensitivity. Clin Exp Allergy 2008;38:199–207.
- 76, . The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 2004;59:809–820.
- 77, . Comparison of the Bayesian approach and a simple algorithm for assessment of adverse drug events. Clin Pharmacol Ther 1995;58:692–698.
- 78. Veterinary pharmacovigilance. Part 5. Causality and expectedness. J Vet Pharmacol Ther 2005;28:203–211.
- 79, . Diagnosis of drug-induced skin reactions: A future role for computer-aided systems? Curr Opin Allergy Clin Immunol 2011;11:451–456.
- 80, . Preventing and managing drug-induced anaphylaxis. Drug Saf 2001;24:843–853.
- 81Medleau L and ed. Small Animal Dermatology: A Color Atlas and Therapeutic Guide. St Louis: Saunders; 2006.
- 82, . Successful intravenous human immunoglobulin treatment of drug-induced Stevens-Johnson syndrome in a dog. J Small Anim Pract 2004;45:357–361.
- 83, , . The use of intravenous human immunoglobulin in treatment of severe pemphigus foliaceus in a dog. J Vet Intern Med 2006;20:1483–1486.
- 84, , , et al. Treatment of severe adverse cutaneous drug reactions with human intravenous immunoglobulin in two dogs. J Am Anim Hosp Assoc 2006;42:312–320.
- 85, . Adverse drug reactions: Types and treatment options. Am Fam Physician 2003;68:1781–1790.
- 86. Delayed drug hypersensitivity reactions. Ann Intern Med 2003;139:683–693.