Work was performed at the University of Tennessee, College of Veterinary Medicine, Knoxville, TN.
Diagnostic Frequency, Response to Therapy, and Long-Term Prognosis among Horses and Ponies with Pituitary Par Intermedia Dysfunction, 1993–2004
Article first published online: 24 APR 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 4, pages 1027–1034, July-August 2012
How to Cite
Rohrbach, B.W., Stafford, J.R., Clermont, R.S.W., Reed, S.M., Schott, H.C. and Andrews, F.M. (2012), Diagnostic Frequency, Response to Therapy, and Long-Term Prognosis among Horses and Ponies with Pituitary Par Intermedia Dysfunction, 1993–2004. Journal of Veterinary Internal Medicine, 26: 1027–1034. doi: 10.1111/j.1939-1676.2012.00932.x
- Issue published online: 13 JUL 2012
- Article first published online: 24 APR 2012
- Manuscript Accepted: 10 MAR 2012
- Manuscript Revised: 21 JAN 2012
- Manuscript Received: 13 MAY 2011
- Centers of Excellence in Livestock Diseases and Human Health, College of Veterinary Medicine, University of Tennessee
- Metabolic disease;
- Pituitary par intermedia dysfunction
Pituitary pars intermedia dysfunction (PPID) is common in older horses.
To determine diagnosis frequency, prognostic factors, long-term survival, and owner satisfaction with treatment.
Medical records from horses diagnosed with PPID, 1993–2004.
A retrospective cohort design with data collected from the Veterinary Medical Data Base (VMDB) and a cohort of 3 VTHs. Proportional accessions, annual incidence, and demographics were compared for all accessions. During the same period, a subset of medical records (n = 44) was extracted and owners (n = 34) contacted to obtain long-term follow-up information.
Diagnoses of PPID were reported for 217 horses that presented to VTHs and were reported to the VMDB. Proportional diagnosis increased from 0.25/1,000 in 1993 to 3.72/1,000 in 2002. For 44 horses included in the follow-up study, the most commons signs were hirsutism (84%) and laminitis (50%). Of 34 horse owners contacted, the average time from onset of signs to diagnosis was 180 days. Improvement in ≥ 1 signs, 2 months after diagnosis, was reported by 9/22 (41%) of horse owners. Clinical signs and clinicopathologic data were not associated with survival, and 50% of horses were alive 4.6 years after diagnosis. Cause of death among horses (15/20; 85%) was euthanasia, and 11/15 (73%) were euthanized because of conditions associated with PPID. Most horse owners (28/29; 97%) said they would treat a second horse for PPID.
Conclusion and Clinical Importance
PPID was diagnosed with increasing frequency, and 50% of horses survived 4.5 years after diagnosis. Owners were satisfied with their horses' quality of life and would treat a second horse if diagnosed.