Prior abstract publication: This work was presented as an oral abstract at the 2009 American College of Veterinary Internal Medicine Forum & Canadian Veterinary Medical Association Convention, Montreal, Quebec, Canada (Serum D-lactate concentrations in cats with gastrointestinal disease).
Serum D-Lactate Concentrations in Cats with Gastrointestinal Disease
Article first published online: 21 APR 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 4, pages 905–910, July-August 2012
How to Cite
Packer, R.A., Moore, G.E., Chang, C.-Y., Zello, G.A., Abeysekara, S., Naylor, J.M., Steiner, J.M., Suchodolski, J.S. and O'Brien, D.P. (2012), Serum D-Lactate Concentrations in Cats with Gastrointestinal Disease. Journal of Veterinary Internal Medicine, 26: 905–910. doi: 10.1111/j.1939-1676.2012.00936.x
- Issue published online: 13 JUL 2012
- Article first published online: 21 APR 2012
- Manuscript Accepted: 15 MAR 2012
- Manuscript Revised: 23 JAN 2012
- Manuscript Received: 20 AUG 2011
- ACVIM Foundation. Grant Number: 07-10D
- D-lactic acid;
Increased D-lactate concentrations cause neurological signs in humans with gastrointestinal disease.
To determine if serum D-lactate concentrations are increased in cats with gastrointestinal disease compared to healthy controls, and if concentrations correlate with specific neurological or gastrointestinal abnormalities.
Systematically selected serum samples submitted to the Gastrointestinal Laboratory at Texas A&M University from 100 cats with clinical signs of gastrointestinal disease and abnormal gastrointestinal function tests, and 30 healthy cats.
Case-control study in which serum D- and L-lactate concentrations and retrospective data on clinical signs were compared between 30 healthy cats and 100 cats with gastrointestinal disease. Association of D-lactate concentration with tests of GI dysfunction and neurological signs was evaluated by multivariate linear and logistic regression analyses, respectively.
All 100 cats had a history of abnormal gastrointestinal signs and abnormal gastrointestinal function test results. Thirty-one cats had definitive or subjective neurological abnormalities. D-lactate concentrations of cats with gastrointestinal disease (median 0.36, range 0.04–8.33 mmol/L) were significantly higher than those in healthy controls (median 0.22, range 0.04–0.87 mmol/L; P = .022). L-lactate concentrations were not significantly different between the 2 groups of cats with gastrointestinal disease and healthy controls. D-lactate concentrations were not significantly associated with fPLI, fTLI, cobalamin, folate, or neurological abnormalities (P > .05).
Conclusions and Clinical Importance
D-lactate concentrations can be increased in cats with gastrointestinal disease. These findings warrant additional investigations into the role of intestinal microbiota derangements in cats with gastrointestinal disease, and the association of D-lactate and neurological abnormalities.