Both authors equally contributed to this article.
Recombinant Human Thyrotropin in Veterinary Medicine: Current Use and Future Perspectives
Version of Record online: 7 JUN 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 4, pages 853–862, July-August 2012
How to Cite
Campos, M., van Hoek, I., Peremans, K. and Daminet, S. (2012), Recombinant Human Thyrotropin in Veterinary Medicine: Current Use and Future Perspectives. Journal of Veterinary Internal Medicine, 26: 853–862. doi: 10.1111/j.1939-1676.2012.00950.x
This work was conducted at Ghent University, Belgium
This article did not receive support from any grant.
This review has not been presented in any meeting.
- Issue online: 13 JUL 2012
- Version of Record online: 7 JUN 2012
- Manuscript Accepted: 21 APR 2012
- Manuscript Revised: 3 APR 2012
- Manuscript Received: 16 OCT 2011
Recombinant human thyrotropin (rhTSH) was developed after bovine thyrotropin (bTSH) was no longer commercially available. It was approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) as an aid to diagnostic follow-up of differentiated thyroid carcinoma in humans and for thyroid remnant ablation with radioiodine. In addition, rhTSH is used in human medicine to evaluate thyroid reserve capacity and to enhance radioiodine uptake in patients with metastatic thyroid cancer and multinodular goiter. Likewise, rhTSH has been used in veterinary medicine over the last decade. The most important veterinary use of rhTSH is thyroidal functional reserve testing for the diagnosis of canine hypothyroidism. Recent pilot studies performed at Ghent University in Belgium have investigated the use of rhTSH to optimize radioiodine treatment of canine thyroid carcinoma and feline hyperthyroidism. Radioiodine treatment optimization may allow a decreased therapeutic dosage of radioiodine and thus may improve radioprotection. This review outlines the current uses of rhTSH in human and veterinary medicine, emphasizing research performed in dogs and cats, as well as potential future applications.