Abstracts of portions of this study were presented in part at the 28th Veterinary Cancer Society Annual Conference in 2008, and at the 2009 ACVIM Forum and Canadian Veterinary Medical Association Convention, Montreal, Quebec, Canada
Histologic and Immunohistochemical Review of Splenic Fibrohistiocytic Nodules in Dogs
Article first published online: 7 AUG 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 5, pages 1164–1168, September–October 2012
How to Cite
Moore, A.S., Frimberger, A.E., Sullivan, N. and Moore, P.F. (2012), Histologic and Immunohistochemical Review of Splenic Fibrohistiocytic Nodules in Dogs. Journal of Veterinary Internal Medicine, 26: 1164–1168. doi: 10.1111/j.1939-1676.2012.00986.x
- Issue published online: 14 SEP 2012
- Article first published online: 7 AUG 2012
- Manuscript Accepted: 26 JUN 2012
- Manuscript Revised: 6 MAY 2012
- Manuscript Received: 9 MAY 2011
Vol. 27, Issue 1, 215, Article first published online: 11 JAN 2013
- Histiocytic sarcoma;
Splenic fibrohistiocytic nodules (SFHN) are commonly diagnosed. It is suspected that these represent a heterogeneous group of malignant and nonmalignant diseases, separation of which could improve the ability of clinicians to prognosticate for dogs.
Immunohistochemistry will differentiate histologic diagnoses within the group of SFHN; survival after splenectomy is associated with those histologic types.
Thirty-two dogs with SFHN treated by or under direction from veterinary oncologists.
Retrospective case record analysis from dogs followed from splenectomy until death. Clinical, histopathologic, and immunohistochemistry data analyzed for an association with survival time.
Thirty-two dogs had SFHN; grade 1 (2 dogs), grade 2 (9 dogs), and grade 3 (lymphoid percentage <40%; 21 dogs). Twenty-two dogs died, 10 were censored (9 alive median of 883 days after splenectomy). Median overall survival was 387 days, and grade 3 SFHN was positively associated with survival time as previously reported (P < .001). Of 31 available samples, dogs had diseases reclassified as nodular hyperplasia (13; 8 complex, 5 lymphoid including 2 marginal zone), lymphoma (4; 2 marginal zone lymphoma, 1 high grade B-cell lymphoma, and 1 marginal zone transitional to high grade B-cell lymphoma), 8 stromal sarcomas, and 6 histiocytic sarcomas. Dogs with histiocytic sarcoma had worse survival (median 74 days) than dogs with other diseases.
Conclusions and Clinical Importance
Splenic histiocytic sarcoma is an aggressive disease; however, some dogs with stromal sarcomas had long survival times. The term SFHN is no longer warranted for this group of disorders.