Fibrinolytic Activity in Cerebrospinal Fluid of Dogs with Different Neurological Disorders
Article first published online: 27 AUG 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 6, pages 1365–1373, November/December 2012
How to Cite
de la Fuente, C., Monreal, L., Cerón, J., Pastor, J., Viu, J. and Añor, S. (2012), Fibrinolytic Activity in Cerebrospinal Fluid of Dogs with Different Neurological Disorders. Journal of Veterinary Internal Medicine, 26: 1365–1373. doi: 10.1111/j.1939-1676.2012.00991.x
- Issue published online: 20 NOV 2012
- Article first published online: 27 AUG 2012
- Manuscript Accepted: 18 JUL 2012
- Manuscript Revised: 29 JUN 2012
- Manuscript Received: 30 MAR 2012
- Intrathecal fibrinolysis;
- C-reactive protein;
Fibrinolytic activity in cerebrospinal fluid (CSF) is activated in humans by different pathologic processes.
To investigate fibrinolytic activity in the CSF of dogs with neurological disorders by measuring CSF D-dimer concentrations.
One hundred and sixty-nine dogs with neurological disorders, 7 dogs with systemic inflammatory diseases without central nervous system involvement (SID), and 7 healthy Beagles were included in the study. Dogs with neurological disorders included 11 with steroid-responsive meningitis-arteritis (SRMA), 37 with other inflammatory neurological diseases (INF), 38 with neoplasia affecting the central nervous system (NEO), 28 with spinal compressive disorders (SCC), 15 with idiopathic epilepsy (IE), and 40 with noninflammatory neurological disorders (NON-INF).
Prospective observational study. D-dimers and C-reactive protein (CRP) were simultaneously measured in paired CSF and blood samples.
D-dimers and CRP were detected in 79/183 (43%) and in 182/183 (99.5%) CSF samples, respectively. All dogs with IE, SID, and controls had undetectable concentrations of D-dimers in the CSF. CSF D-dimer concentrations were significantly (P < .001) higher in dogs with SRMA than in dogs with other diseases and controls. CSF CRP concentration in dogs with SRMA was significantly (P < .001) higher than in dogs of other groups and controls, except for the SID group. No correlation was found between blood and CSF D-dimer concentrations.
Conclusions and Clinical Importance
Intrathecal fibrinolytic activity seems to be activated in some canine neurological disorders, and it is high in severe meningeal inflammatory diseases. CSF D-dimer concentrations may be considered a diagnostic marker for SRMA.