• 1
    Hoffmann G, Van Den Ingh TSGAM, Bode P, Rothuizen J. Copper-associated chronic hepatitis in Labrador Retrievers. J Vet Intern Med 2006;20:856861.
  • 2
    Shih JL, Keating JH, Freeman LM, Webster CRL. Chronic hepatitis in Labrador Retrievers: Clinical presentation and prognostic factors. J Vet Intern Med 2007;21:3339.
  • 3
    Smedley R, Mullaney T, Rumbeiha W. Copper-associated hepatitis in Labrador Retrievers. Vet Pathol 2009;46:484490.
  • 4
    Subcommittee on Dog and Cat Nutrition, Committee on Animal Nutrition, National Research Council. Nutrient Requirements of Dogs and Cats. Washington, DC: The National Academy Press; 2006.
  • 5
    Hoffmann G, Jones PG, Biourge V, et al. Dietary management of hepatic copper accumulation in Labrador Retrievers. J Vet Intern Med 2009;23:957963.
  • 6
    Schilsky ML. Treatment of Wilson's disease: What are the relative roles of penicillamine, trientine, and zinc supplementation? Curr Gastroenterol Rep 2001;3:5459.
  • 7
    Yuzbasiyan-Gurkan V, Grider A, Nostrant T, et al. Treatment of Wilson's disease with zinc: X. Intestinal metallothionein induction. J Lab Clin Med 1992;120:380386.
  • 8
    Brewer GJ, Dick RD, Schall W, et al. Use of zinc acetate to treat copper toxicosis in dogs. J Am Vet Med Assoc 1992;201:564568.
  • 9
    Rothuizen J, Desmet VJ, Van Den Ingh TSGAM, et al. Sampling and handling of liver tissue. In: Rodenhuis J, ed. WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Disease – WSAVA Liver Standardization Group. Philadelphia, PA: Elsevier; 2006:514.
  • 10
    Van Den Ingh TSGAM, Van Winkle T, Cullen JM, et al. Morphological classification of parenchymal disorders of the canine and feline liver. 2. Hepatocellular death, hepatitis and cirrhosis. In: WSAVA Liver Standardization Group, ed. WSAVA Standards for Clinical and Histological Diagnosis of Canine Liver Diseases. Philadelphia, PA: Elsevier; 2006:85101.
  • 11
    Bode P. Instrumental neutron activation analysis in a routine way. J Trace Microprobe Tech 1990;8:139154.
  • 12
    Association Française de Normalisation. 1981. Official Publication. Assoc. Française de Normalisation, Paris, France.
  • 13
    Association of American Feed Control Officials (AAFCO). Dogs and Cats Nutrient Profiles. Oxford, IN: AAFCO. 2011:146162.
  • 14
    R Development Core Team. R: A Language and Environment for Statistical Computing. R Development Core Team, Vienna, Austria; 2011.
  • 15
    Puls R. Mineral Concentrations in Animal Health, 2nd ed. Clearbrook, BC, Canada: Sherpa International; 1994.
  • 16
    Cole TL, Center SA, Flood SN, et al. Diagnostic comparison of needle and wedge biopsy specimens of the liver in dogs and cats. J Am Vet Med Assoc 2002;220:14831490.
  • 17
    Johnston AN, Center SA, McDonough SP, Warner KL. Influence of biopsy specimen size, tissue fixation, and assay variation on copper, iron, and zinc concentrations in canine livers. Am J Vet Res 2009;70:15021511.
  • 18
    Sternlieb I. Copper and the liver. Gastroenterology 1980;78:16151628.
  • 19
    Danks DM. Copper and liver disease. Eur J Pediatr 1991;150:142148.
  • 20
    Hill RC, Choate CJ, Scott KC, Molenberghs G. Comparison of the guaranteed analysis with the measured nutrient composition of commercial pet foods. J Am Vet Med Assoc 2009;234:347351.
  • 21
    Van Den Ingh TSGAM, Punte PM, Hoogendijk ENLJ, Rothuizen J. Possible nutritionally induced copper-associated chronic hepatitis in two dogs. Vet Rec 2007;161:728729.
  • 22
    Haywood S, Simpson DM, Ross G, Beynon RJ. The greater susceptibility of North Ronaldsay sheep compared with Cambridge sheep to copper-induced oxidative stress, mitochondrial damage and hepatic stellate cell activation. J Comp Pathol 2005;133:114127.
  • 23
    Steffen DJ, Carlson MP, Casper HH. Copper toxicosis in suckling beef calves associated with improper administration of copper oxide boluses. J Vet Diagn Invest 1997;9:443446.
  • 24
    Muller T, Feichtinger H, Berger H, Muller W. Endemic tyrolean infantile cirrhosis: An ecogenetic disorder. Lancet 1996;347:877880.
  • 25
    Muller T, Muller W, Feichtinger H. Idiopathic copper toxicosis. Am J Clin Nutr 1998;67:1082S1086S.
  • 26
    Pandit A, Bhave S. Present interpretation of the role of copper in Indian childhood cirrhosis. Am J Clin Nutr 1996;63:830S835S.
  • 27
    O'Donohue J, Reid M, Varghese A, et al. A case of adult chronic copper self-intoxication resulting in cirrhosis. Eur J Med Res 1999;4:252.
  • 28
    Scheinberg IH, Sternlieb I. Wilson disease and idiopathic copper toxicosis. Am J Clin Nutr 1996;63:842S845S.
  • 29
    Fieten H, Leegwater PA, Watson AL, Rothuizen J. Canine models of copper toxicosis for understanding mammalian copper metabolism. Mamm Genome 2012;23:6275.
  • 30
    Hoffmann G, Heuven HC, Leegwater PA, et al. Heritabilities of copper-accumulating traits in Labrador Retrievers. Anim Genet 2008;39:454.