Work was completed on the Wagga Wagga campus of Charles Sturt University, NSW, Australia. The results of this study have not been presented or published previously
Effects of Meloxicam and Phenylbutazone on Equine Gastric Mucosal Permeability
Article first published online: 20 OCT 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 6, pages 1494–1499, November/December 2012
How to Cite
D'Arcy-Moskwa, E., Noble, G.K., Weston, L.A., Boston, R. and Raidal, S.L. (2012), Effects of Meloxicam and Phenylbutazone on Equine Gastric Mucosal Permeability. Journal of Veterinary Internal Medicine, 26: 1494–1499. doi: 10.1111/j.1939-1676.2012.01004.x
- Issue published online: 20 NOV 2012
- Article first published online: 20 OCT 2012
- Manuscript Accepted: 14 AUG 2012
- Manuscript Revised: 10 JUN 2012
- Manuscript Received: 30 OCT 2011
- Troy Laboratories
- Gastric ulceration;
- Nonsteroidal anti-inflammatory drugs;
- Sucrose permeability
Newer NSAIDs that more selectively target the induced isoform of the cyclooxygenase enzyme (COX2) activity might reduce adverse effects while preserving therapeutic benefits of these drugs.
To compare the effect of oral administration of multiple dose rates of meloxicam and phenylbutazone (PBZ) on gastric mucosal integrity in horses.
Twenty-five light breed horses.
In vivo toxicity study. Horses were randomly assigned to 5 treatment groups, receiving placebo, PBZ (4.4 mg/kg PO q12h day 1, 2.2 mg/kg PO q12h for 4 days, 2.2 mg/kg PO q24h for 9 days), or 3 dose rates of meloxicam (0.6 mg/kg q24h, 1.8 mg/kg q24h, 3.0 mg/kg q24h) for 14 days. Sucrose permeability testing was performed on Day 0 (before treatment) and on Day 13. All personnel involved with data collection or analysis were blinded to treatment.
Administration of PBZ at the above dose rate significantly increased gastric permeability to sucrose, evidenced by increased peak serum sucrose concentrations (280–1,580 pg/μL, P = .001) after treatment. Similar changes were not evident after administration of meloxicam at any dose rate tested, or in control horses (P > .05). Treatment was not associated with significant differences in ulceration of the squamous or glandular mucosa. Peak sucrose concentrations were not correlated with serum total protein or albumin concentrations (R2 = −0.07, P = .61, R2 = −0.08, P = .58, respectively).
Conclusion and Clinical Importance
These results suggest that PBZ was associated with greater compromise to gastric mucosal integrity than meloxicam.