• 1
    Refetoff S, Dumont J, Vassart G. Thyroid disorders. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic & Molecular Bases of Inherited Disease, 8th ed. New York: McGraw-Hill; 2001:40294064.
  • 2
    Chastain CB, McNeel SV, Graham CL, et al. Congenital hypothyroidism in a dog due to an iodide organification defect. Am J Vet Res 1983;44:12571265.
  • 3
    Fyfe JC, Kampschmidt K, Dang V, et al. Congenital hypothyroidism with goiter in Toy Fox Terriers. J Vet Intern Med 2003;17:5057.
  • 4
    Thompson T. Iodine-deficiency goitre in a bitch. N Z Vet J 1979;27:113.
  • 5
    Seelig DM, Whittemore JC, Lappin MR, et al. Goitrous hypothyroidism associated with treatment with trimethoprim-sulfamethoxazole in a young dog. J Am Vet Med Assoc 2008;232:11811185.
  • 6
    Castillo VA, Lalia JC, Junco M, et al. Changes in thyroid function in puppies fed a high iodine commercial diet. Vet J 2001;161:8084.
  • 7
    Castillo VA, Pisarev MA, Lalia JC, et al. Commercial diet induced hypothyroidism due to high iodine. A histological and radiological analysis. Vet Q 2001;23:218223.
  • 8
    Park SM, Chatterjee VKK. Genetics of congenital hypothyroidism. J Med Genet 2005;42:379389.
  • 9
    Vulsma T, De Vijlder JJM. Genetic defects causing hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text, 9th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2005:714730.
  • 10
    Ruf J, Carayon P. Structural and functional aspects of thyroid peroxidase. Arch Biochem Biophys 2006;445:269277.
  • 11
    Arnold U, Opitz M, Grossier I. Goitrous hypothyroidism and dwarfism in a kitten. J Am Anim Hosp Assoc 1984;20:753758.
  • 12
    Jones BR, Gruffydd-Jones TJ, Sparkes AH, Lucke VM. Preliminary studies on congenital hypothyroidism in a family of Abyssinian cats. Vet Rec 1992;131:145148.
  • 13
    Mazrier H, French A, Ellinwood NM, et al. Goitrous congenital hypothyroidism caused by thyroid peroxidase deficiency in a family of domestic shorthair cats. J Vet Intern Med 2003;17:395396.
  • 14
    Brouwers J. GoÎtre et hérédité chez le chien. Ann de Méd Vét [Liège, FR] 1950;94:173174.
  • 15
    Pettigrew R, Fyfe JC, Gregory BL, et al. CNS hypomyelination in Rat Terrier dogs with congenital goiter and a mutation in the thyroid peroxidase gene. Vet Pathol 2007;44:5056.
  • 16
    Bojanic K, Acke E, Jones BR. Congenital hypothyroidism of dogs and cats: A review. NZ Vet J 2011;59:115122.
  • 17
    Nakashima T, Taurog A. Improved assay procedures for thyroid peroxidase; application to normal and adenomatous human thyroid tissue. Clin Chim Acta 1978;83:129140.
  • 18
    Xu D, Fyfe JC. Cubilin expression and posttranslational modification in the canine gastrointestinal tract. Am J Physiol Gastrintest Liver Physiol 2000;279:G748G756.
  • 19
    Kawasaki ES. Sample preparation from blood, cells, and other fluids. In: Innis MA, Gelfand DH, Sninsky JJ, White TJ, eds. PCR Protocols: Guide to Methods and Applications. San Diego, CA: Academic Press; 1990:146152.
  • 20
    Marchler-Bauer A, Anderson JB, Chitsaz F, et al. CDD: Specific functional annotation with the Conserved Domain Database. Nucleic Acids Res 2009;37(D):205210.
  • 21
    Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009;4:10731081.
  • 22
    Adzhubei IA, Schmidt S, Peshkin L, et al. A method and server for predicting damaging missense mutations. Nat Methods 2010;7:248249.
  • 23
    DeLano WL. The PyMOL Molecular Graphics System (2002) DeLano Scientific, Palo Alto, CA (
  • 24
    Seed RW, Goldberg IH. Iodination in relation to thyroglobulin maturation and subunit aggregation. Science 1965;149:13801382.
  • 25
    Frati L, Bilstad J, Edelhoch H, et al. Biosynthesis of the 27 S thyroid iodoprotein. Arch Biochem Biophys 1974;162:126134.
  • 26
    Arvan P, Di Jeso B. Thyroglobulin structure, function, and biosynthesis. In: Braverman LE, Utiger RD, eds. Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text, 9th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2005:7795.
  • 27
    Ris-Stalpers C, Bikker H. Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. Mol Cell Endocrinol 2010;322:3843.
  • 28
    Taurog A, Dorris ML. Myeloperoxidase-catalyzed iodination and coupling. Arch Biochem Biophys 1992;296:239246.
  • 29
    Furtmuller PG, Zederbauer M, Jantschko W, et al. Active site structure and catalytic mechanisms of human peroxidases. Arch Biochem Biophys 2006;445:199213.
  • 30
    Fayadat L, Niccoli-Sire P, Lanet J, Franc J-L. Role of heme in intracellular trafficking of thyroperoxidase and involvement of H2O2 generated at the apical surface of thyroid cells in autocatalytic covalent heme binding. J Biol Chem 1999;274:1053310538.