This study was performed at the Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Din Veterinär Animal Hospital, Helsingborg, Sweden, and Blå Stjärnans Animal Hospital, Gothenburg, Sweden.
Radial and Longitudinal Strain and Strain Rate Assessed by Speckle-Tracking Echocardiography in Dogs with Myxomatous Mitral Valve Disease
Article first published online: 1 NOV 2012
Copyright © 2012 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 26, Issue 6, pages 1309–1319, November/December 2012
How to Cite
Zois, N.E., Tidholm, A., Nägga, K.M., Moesgaard, S.G., Rasmussen, C.E., Falk, T., Häggström, J., Pedersen, H.D., Åblad, B., Nilsen, H.Y. and Olsen, L.H. (2012), Radial and Longitudinal Strain and Strain Rate Assessed by Speckle-Tracking Echocardiography in Dogs with Myxomatous Mitral Valve Disease. Journal of Veterinary Internal Medicine, 26: 1309–1319. doi: 10.1111/j.1939-1676.2012.01017.x
Preliminary results from this study were presented at the 21st European College of Veterinary Internal Medicine Congress in Seville, Spain, 2011
- Issue published online: 20 NOV 2012
- Article first published online: 1 NOV 2012
- Manuscript Accepted: 5 SEP 2012
- Manuscript Revised: 25 JUL 2012
- Manuscript Received: 21 DEC 2011
- Faculty of Life Sciences, University of Copenhagen
- Danish Council of Independent Research, Medical Sciences. Grant Number: 271-08-0998
- Deformation Rate;
- Mitral regurgitation;
- Ventricular function
Assessment of left ventricular (LV) function using conventional echocardiographic methods is difficult in mitral regurgitation (MR) owing to altered hemodynamic loading conditions. Newer methods such as speckle-tracking echocardiography (STE) provide assessment of LV strain (St) and strain rates (SR).
Global St and SR are 1) decreased in dogs with clinical signs of congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) compared with clinically healthy dogs, and are 2) associated with conventional echocardiographic indices of MMVD severity.
The study subjects were 93 privately owned dogs with different MMVD severities.
Prospectively recruited dogs were grouped according to MMVD severity based on echocardiographic evaluation of MR and presence of clinical signs. Global radial and longitudinal St, SR, and indices of LV dyssynchrony were assessed.
On group-wise comparisons, dogs with CHF had increased global longitudinal St, global longitudinal and radial SR in systole (SRs), and early diastole (SRe) compared with dogs with no or minimal MR (all P < .04). On multiple regression analyses, these global STE variables increased with degree of MR, but associations with left atrial-to-aortic root ratio (LA/Ao) were best described by second-order polynomial equations. Thus, curvilinear relationships were found for LA/Ao and longitudinal St, SRs, and SRe (all P < .002) and radial St and SRe (all P < .001).
Conclusions and Clinical Importance
Assessed by STE, LV function appeared to be augmented in moderate-to-severe disease. However, at CHF stages with greatly enlarged atria, a decrease to levels comparable to dogs with no or minimal MR was observed.