This work was supported by a grant from the National Alliance for Research in Schizophrenia and Depression (NARSAD) (PI Linker). This study was supported by Grants MH-55557, MH-62368 (JLS), and MH-068521 (LJE) from the National Institute of Mental Health and UL1RR031990 from the National Center for Research Resources. We want to thank the Mid-Atlantic Twin Registry (MATR) for the recruitment of twin families.
Suicidal Ideation, Depression, and Conduct Disorder in a Sample of Adolescent and Young Adult Twins
Article first published online: 30 MAY 2012
© 2012 The American Association of Suicidology
Suicide and Life-Threatening Behavior
Volume 42, Issue 4, pages 426–436, August 2012
How to Cite
Linker, J., Gillespie, N. A., Maes, H., Eaves, L. and Silberg, J. L. (2012), Suicidal Ideation, Depression, and Conduct Disorder in a Sample of Adolescent and Young Adult Twins. Suicide and Life-Threat Behavi, 42: 426–436. doi: 10.1111/j.1943-278X.2012.00101.x
- Issue published online: 27 AUG 2012
- Article first published online: 30 MAY 2012
- Manuscript Received: November 28, 2011 Revision Accepted: March 28, 2012
The co-occurrence of suicidal ideation, depression, and conduct disturbance is likely explained in part by correlated genetic and environmental risk factors. Little is known about the specific nature of these associations. Structured interviews on 2,814 twins from the Virginia Twin Study of Adolescent Behavioral Development (VTSABD) and Young Adult Follow-Up (YAFU) yielded data on symptoms of depression, conduct disorder, and adolescent and young adult suicidal ideation. Univariate analyses revealed that the familial aggregation for each trait was explained by a combination of additive genetic and shared environmental effects. Suicidal ideation in adolescence was explained in part by genetic influences, but predominantly accounted for by environmental factors. A mixture of genetic and shared environmental influences explained ideation occurring in young adulthood. Multivariate analyses revealed that there are genetic and shared environmental effects common to suicidal ideation, depression, and conduct disorder. The association between adolescent suicidal ideation and CD was attributable to the same genetic and environmental risk factors for depression. These findings underscore that prevention and intervention strategies should reflect the different underlying mechanisms involving depression and conduct disorder to assist in identifying adolescents at suicidal risk.