SEARCH

SEARCH BY CITATION

References

  • 1
    Fujita T, Inoue K, Yamamoto S, et al. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot 1994; 47: 208215.
  • 2
    Kiuchi M, Adachi K, Kohara T, et al. Synthesis and immunosuppressive activity of 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols. J Med Chem 2000; 43: 29492961.
  • 3
    Brinkmann V, Pinschewer D, Chiba K, et al. FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation. Trends Pharmacol Sci 2000; 1: 4952.
  • 4
    Tsunemi S, Iwasaki T, Kitano S, et al. Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model. Clin Immunol 2010; 136: 197204.
  • 5
    Kohno T, Tsuji T, Hirayama K, et al. A novel immunomodulator, FTY720, prevents development of experimental autoimmune myasthenia gravis in C57BL/6 mice. Biol Pharm Bull 2005; 28: 736739.
  • 6
    Yoshida Y, Tsuji T, Fujita T, et al. Relapse of experimental autoimmune encephalomyelitis after discontinuation of FTY720 (fingolimod) treatment, but not after combination of FTY720 and pathogenic autoantigen. Biol Pharm Bull 2011; 34: 933936.
  • 7
    Kohno T, Tsuji T, Hirayama K, et al. A novel immunomodulator, FTY720, prevents spontaneous dermatitis in NC/Nga mice. Biol Pharm Bull 2004; 27: 13921396.
  • 8
    Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277: 2145321457.
  • 9
    Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004; 427: 355360.
  • 10
    Gräler MH, Goetzl EJ. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J 2004; 18: 551553.
  • 11
    Chiba K, Yanagawa Y, Masubuchi Y, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J Immunol 1998; 160: 50375044.
  • 12
    Yanagawa Y, Sugahara K, Kataoka H, et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J Immunol 1998; 160: 54935499.
  • 13
    Makino S, Kunimoto K, Muraoka Y, et al. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 1980; 29: 113 (Japanese).
  • 14
    Kaino Y, Ito T, Goto Y, et al. Lack of recurrence of insulin-dependent diabetes mellitus in syngeneic and allogeneic islet-transplanted diabetic biobreeding rats. Transplantation 1998; 65: 15431548.
  • 15
    Kaino Y, Hirai H, Ito T, et al. Prevention of diabetes in non-obese diabetic (NOD) mice by short-term and high-dose IGF-I treatment. J Pediatr Endocrinol Metab 1998; 11: 267272.
  • 16
    Zhang J, Tokui Y, Yamagata K, et al. Continuous stimulation of human glucagon-like peptide-1 (7–36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes. Diabetologia 2007; 50: 19001909.
  • 17
    Mu J, Petrov A, Eiermann GJ, et al. Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Eur J Pharmacol 2009; 623: 148154.
  • 18
    Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010; 362: 402415.
  • 19
    Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology 2008; 71: 12611267.
  • 20
    Kappos L, Radue EW, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010; 362: 387401.
  • 21
    Maki T, Gottschalk R, Monaco AP. Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice. Transplantation 2002; 74: 16841686.
  • 22
    Maki T, Gottschalk R, Ogawa N, et al. Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. Transplantation 2005; 79: 10511055.
  • 23
    Itoh A, Maki T. Protection of nonobese diabetic mice from autoimmune diabetes by reduction of islet mass before insulitis. Proc Natl Acad Sci USA 1996; 93: 1105311056.