Appendix S1 Materials and Methods, providing detailed description of vector construction for the homologous replacement of the mouse IAPP gene for the wild-type and S20G mutant hIAPP in mouse embryonic stem cells and subsequent generation of the wild-type and S20G mutant hIAPP knock-in mice.

Appendix S2 Intraislet amyloidogenesis in WW and GW chimaeric 129Sv/E founder mice at 15 months.

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