Antidiuretic response of a horse affected with pituitary pars intermedia dysfunction to desmopressin acetate

Authors

  • M. E. Moses,

    1. Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA
    2. Steilacoom, Washington, USA
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  • P. J. Johnson,

    Corresponding author
    1. Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA
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  • N. T. Messer,

    1. Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA
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  • D. A. Wilson

    1. Department of Veterinary Medicine and Surgery, Veterinary Medical Teaching Hospital, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA
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email: johnsonpj@missouri.edu

Summary

Central diabetes insipidus (DI) was diagnosed in a 20-year-old American Quarter Horse gelding that was concomitantly affected with pituitary pars intermedia dysfunction (PPID). The diagnosis of DI was supported by a positive response to administered desmopressin acetate. Diagnosis of PPID was supported by physical appearance and elevated plasma adrenocorticotropic hormone concentration following domperidone administration. The horse's physical condition improved following treatment with pergolide but long-term treatment with desmopressin was not undertaken and severe polyuria and polydipsia persisted. Desmopressin acetate appears to be useful for the diagnosis of DI in mature horses concomitantly affected with PPID.

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