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Successful outcome in a case of equine multinodular pulmonary fibrosis (EMPF) treated with valacyclovir


  • Case was presented as part of an oral presentation at the 50th BEVA Congress in Liverpool, UK; 7th-10th Sept 2011 with abstract in proceedings (p 83).



Equine multinodular pulmonary fibrosis (EMPF) is a progressive fibrosing interstitial lung disease, which has been associated with γ-herpesviruses. This report describes a 22-year-old Warmblood stallion diagnosed with EMPF on the basis of clinical examination, laboratory results, lung radiographs and ultrasound, lung biopsy and inclusion bodies found in macrophages of broncho-alveolar lavage fluid (BALF) as well as an identification of EHV-5 DNA by polymerase chain reaction (PCR). The horse recovered after one week of treatment with valacyclovir (40 mg/kg bwt per os q. 8 h) and is clinically healthy 2 years later. To our knowledge this is the first report describing treatment of EMPF with valacyclovir.