Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony

Authors

  • J. N. MOORE,

    1. The Middlebush Equine Center, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, USA
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    • *

      Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA

  • H. E. GARNER,

    1. The Middlebush Equine Center, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, USA
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  • J. E. SHAPLAND,

    1. The Middlebush Equine Center, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, USA
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  • D. G. HATFIELD

    1. The Middlebush Equine Center, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, USA
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Abstract

Summary

Bacterial endotoxin injected intravenously into conscious ponies produced alterations in cardiopulmonary and gastrointestinal function. Specifically, tachypnoea, dyspnoea, hypoxaemia, colic, lactic acidosis and diarrhoea resulted from administration of 10μg/kg Escherichia coli endotoxin. Pretreatment of the ponies with a potent prostaglandin synthetase inhibitor, flunixin meglumine, prevented these ill effects of endotoxin.

Résumé

Des endotoxines bactériennes injectées par voie intraveineuse à des poneys conscients, engendrèrent des altérations des fonctions pulmonaires et gastro intestinales. En particulier de la tachypnée, de la dyspnée, de l'hypoxie, des coliques, de l'acidose lactique et de la diarrhée résultèrent de l'administration d'endotoxines colibacillaires. Le traitement préalable des poneys avec un puissant inhibiteur de la synthèse des prostaglandines, la flunixin méglumine, empêcha ces effets néfastes de l'endotoxine.

Zusammenfassung

Intravenös gegebenes, bakterielles Endotoxin verursachte cardiopulmonäre und gastrointestinale Funktionsstörungen bei Ponies. Eine Dosis von 10 μg Coli-Endotoxin pro kg Körpergewicht rief Tachypnoe, Dyspnoe, Hypoxaemie, Kolik, Lactacidose und Diarrhoe hervor. Eine vorangehende Behandlung der Ponies mit einem wirksamen Prostaglandin-Synthesehemmer (Flunixin Meglumin) vermochte die Endotoxinwirkung zu unterdrücken.

Ancillary