Low dose flunixin meglumine: Effects on eicosanoid production and clinical signs induced by experimental endotoxaemia in horses

Authors

  • SUSAN D. SEMRAD,

    1. Departments of Large Animal Medicine and Physiology-Pharmacology, College of Veterinary Medicine, Athens, Georgia 30602, USA
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    • 3

      School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, Wisconsin 53706, USA.

  • G. E. HARDEE,

    1. Department of Pharmaceutics, University of Georgia, Athens, Georgia 30602, USA
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      Upjohn Company, Kalamazoo, Michigan 49001.

  • MARILYN M. HARDEE,

    1. Departments of Large Animal Medicine and Physiology-Pharmacology, College of Veterinary Medicine, Athens, Georgia 30602, USA
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      Upjohn Company, Kalamazoo, Michigan 49001.

  • J. N. MOORE

    1. Departments of Large Animal Medicine and Physiology-Pharmacology, College of Veterinary Medicine, Athens, Georgia 30602, USA
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Summary

The efficacy of low doses of flunixin meglumine in reducing eicosanoid generation and clinical signs in response to experimentally induced endotoxaemia was investigated. Thromboxane H2 and 6-keto-prostaglandin F were measured in serum and plasma by radioimmunoassay. Plasma flunixin concentrations were determined by high performance liquid chromatography and pharmacokinetic parameters derived non-compartmentally. In horses administered flunixin meglumine before endotoxin challenge, a significant suppression in plasma thromboxane B2 and 6-keto-prostaglandin F generation was observed. Elevations in blood lactate were significantly suppressed in horses pre-treated with 0.25 mg/kg bodyweight flunixin meglumine. Reduction of the clinical signs of endotoxaemia by flunixin meglumine was dose dependent. Low doses of flunixin inhibited eicosanoid production without masking all of the physical manifestations of endotoxaemia necessary for accurate clinical evaluation of the horse's status.

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