Molecular Genetics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
Proteolytic enzymes in equine joints with infectious arthritis
Article first published online: 23 APR 2010
© 1994 EVJ Ltd
Equine Veterinary Journal
Volume 26, Issue 1, pages 48–50, January 1994
How to Cite
SPIERS, S., MAY, S. A., HARRISON, L. J., BENNETT, D. and EDWARDS, G. B. (1994), Proteolytic enzymes in equine joints with infectious arthritis. Equine Veterinary Journal, 26: 48–50. doi: 10.1111/j.2042-3306.1994.tb04330.x
Royal Veterinary College, North Mymms, Hatfield, Herts AL9 TTA, UK.
- Issue published online: 23 APR 2010
- Article first published online: 23 APR 2010
- Received for publication: 13.1.93; Accepted 28.6.93
- infectious arthritis;
- proteolytic enzymes;
- synovial fluid
Significant amounts of collagenase and caseinase activity were detected in infected synovial fluid samples. Partial characterisation of the enzymes by gel filtration suggested that synovial fluid from cases of infectious arthritis may contain enzymes from both the synovial cells and neutrophils. This finding was also supported by analysis of sequential synovial fluid samples from 4 infected joints. In 3 joints the concentration of caseinase and in 1 joint collagenase paralleled the decline in total nucleated cell count. However, in 3 joints the concentration of collagenase remained high after the total nucleated cell count had returned to normal, suggesting that this enzyme originated from resident articular cells.