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Table S1: Description of population cohorts. Sample Set I comprised n = 150 performing Thoroughbreds. Sample Set II (n = 148) was refined to include individuals with no shared sires or dams within each cohort.

Table S2: Designed amplicons in candidate genes.

Table S3: Overlapping PCR primers for re-sequencing COX4I2.

Table S4: A panel of 28 SNPs in 12 genes were genotyped in Sample Set I.

Table S5: A panel of 19 SNPs in 5 genes were genotyped in Sample Set II.

Table S6: Novel SNPs discovered by re-sequencing.

Table S7: Case-control association test results for a panel of 28 SNPs in 12 genes were genotyped in Sample Set I.

Table S8: Case-control association test results for a panel of 19 SNPs in 5 genes that were genotyped in Sample Set II.

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