Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals
Article first published online: 27 NOV 2012
© 2012 EVJ Ltd
Equine Veterinary Journal
Special Issue: 58th Annual Convention of the American Association of Equine Practitioners. Guest Editors: N. White, D. Sellon and B. Ball. Publication of this supplement was supported by the American Association of Equine Practitioners
Volume 44, Issue Supplement S43, pages 73–77, December 2012
How to Cite
Jenvey, C., Caraguel, C., Howarth, G. B. and Riley, C. B. (2012), Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals. Equine Veterinary Journal, 44: 73–77. doi: 10.1111/j.2042-3306.2012.00648.x
- Issue published online: 27 NOV 2012
- Article first published online: 27 NOV 2012
- Manuscript Accepted: 23 JUL 2012
- Manuscript Received: 1 MAR 2012
Reasons for performing the study
Prior to the start of endogenous production of immunoglobulins (Igs), absorption of maternal Igs is important to protect against pathogens in the early neonatal period. It is possible that mare- or foal-associated factors may influence neonatal IgA concentrations.
The temporal relationships among serum and milk IgA concentrations in Thoroughbred mare–foal pairs were explored to determine if periparturient mare- and foal-associated factors contribute to the prediction of foal serum IgA concentrations.
Blood and milk samples as well as complete veterinary records, were collected for 84 Thoroughbred mare–foal pairs from one month before to 2 months after parturition. Samples were tested using enzyme-linked immunosorbent assay (ELISA) for concentrations of IgA. Pairwise correlation coefficients were estimated (P<0.01) and simple linear regression used to investigate unconditional associations between mare IgA levels, mare and foal risk factors and foal serum IgA concentration at 12 h. Backwards, stepwise elimination of nonsignificant factors was used to create a final model.
There were significant temporal relationships among mare serum IgA and among colostrum and milk IgA concentrations within mares (P<0.01). Mare serum IgA concentrations up to one month before parturition were associated with foal serum IgA concentrations at all time points and with colostrum and milk IgA concentrations. Mare serum IgA at -28 days and parity were associated with foal serum IgA concentration at 12 h (P<0.001).
Mare serum IgA concentrations up to 28 days before parturition, together with mare parity, are indicative of neonatal foal serum IgA concentrations.
Mare serum and colostrum IgA concentrations may be useful peripartum predictors of neonatal mucosal immune status, enabling earlier intervention to prevent the consequences of mucosal infections.