THE EMULSIFYING PROPERTIES OF POLYETHYLENEGLYCOL ETHERS OF CETOSTEARYL ALCOHOL

Authors


Summary

  • 1A preliminary survey of the pharmaceutical uses of a series of polyethyleneglycol ethers of cetostearyl alcohol has been made.
  • 2When used alone, the lower members of the series (2 or 4 ethylene oxide units) are more effective than the higher members in emulsifying both liquid paraffin and arachis oil.
  • 3In combination with cetostearyl alcohol, the ethers produce satisfactory non-ionic emulsifying waxes and the variation in emulsifying power is then less marked.
  • 4Non-ionic emulsifying waxes prepared from the members containing 6 or 10 ethylene oxide units were equally effective in emulsifying 70 per cent, of liquid paraffin or arachis oil.
  • 5The compatibility of a non-ionic emulsifying ointment containing cetomacrogol 1000 with a range of dermatological medicaments has been determined.
  • 6Evidence has been produced to suggest the formation of addition compounds between phenolic substances and the ethylene oxide derivatives.
  • 7A water-soluble ointment base suitable for chloramphenicol is suggested.

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