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Chronic administration of physalaemin and isoprenaline to rats produced a significant salivary glands enlargement which was moderate (34% fresh weight increase and 48% dry weight increase compared with control glands) after the peptide administration and striking after the amine (630% fresh weight increase and 600% dry weight increase compared with control glands). Physalaemin caused only hypertrophy of the gland, whereas isoprenaline induced a marked hyperplasia.