Antagonism of prostaglandin F induced bronchoconstriction and blood pressure changes by polyphloretin phosphate in the guinea-pig and cat

Authors

  • A. A. MATHÉ,

    1. Department of Physiology and Department of Pharmacology, Karolinska Institutet, Stockholm and Department of Pharmacology, AB Leo, Helsingborg, Sweden
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    • Psychophysiology Laboratory, Division of Psychiatry, Boston University School of Medicine, Boston, Mass., USA.

  • Dr. K. STRANDBERG,

    Corresponding author
    1. Department of Physiology and Department of Pharmacology, Karolinska Institutet, Stockholm and Department of Pharmacology, AB Leo, Helsingborg, Sweden
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  • B. FREDHOLM

    1. Department of Physiology and Department of Pharmacology, Karolinska Institutet, Stockholm and Department of Pharmacology, AB Leo, Helsingborg, Sweden
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Department of Pharmacology, Karolinska Institutet, 10401, Stockholm 60, Sweden.

Abstract

Polyphloretin phosphate (PPP) when infused intravenously into guinea-pigs or cats antagonized the bronchoconstriction and blood pressure changes elicited by prostaglandin F and cat paw slow reacting substance (SRS). The dose required to induce a 50% reduction was 40–80 mg/kg PPP. The effects of histamine were not significantly antagonized by the doses used. PPP itself also had a blood pressure lowering effect. The results suggest that it may act as a prostaglandin and SRS antagonist in vivo.

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