Effect of myrcene on nociception in mice

Authors

  • V. S. N. RAO,

    Corresponding author
    1. Department of Physiology and Pharmacology, Health Sciences Center, Federal University of Ceará, Caixa Postal-657, 60000 Fortaleza, CE, Brazil
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  • A. M. S. MENEZES,

    1. Department of Physiology and Pharmacology, Health Sciences Center, Federal University of Ceará, Caixa Postal-657, 60000 Fortaleza, CE, Brazil
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  • G. S. B. VIANA

    1. Department of Physiology and Pharmacology, Health Sciences Center, Federal University of Ceará, Caixa Postal-657, 60000 Fortaleza, CE, Brazil
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Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal do Ceará, Caixa Postal 657, 60.000, Fortaleza, CE, Brazil.

Abstract

Abstract— Myrcene, a monoterpene isolated from lemon grass oil (Cymbopogon citratus) has been investigated for antinociception in mice by a low temperature (51.5 ± 0.5°C) hot plate method and by the acetic acid-induced writhing test. Significant inhibition of nociception was seen in the tests with myrcene at doses of 10 and 20 mg kg−1 (i.p.) or at 20 and 40 mg kg−1 (s.c), respectively. The antinociceptive effect was significantly antagonized by naloxone (1 mg kg−1) or yohimbine (2 mg kg−1). The results suggest that myrcene is capable of inducing antinociception in mice, probably mediated by α2-adrenoceptor stimulated release of endogenous opioids.

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