Synthesis, Physical Properties, Toxicological Studies and Bioavailability of L-Pyroglutamic and L-Glutamic Acid Esters of Paracetamol as Potentially Useful Prodrugs
Version of Record online: 12 APR 2011
1996 Royal Pharmaceutical Society of Great Britain
Journal of Pharmacy and Pharmacology
Volume 48, Issue 5, pages 479–485, May 1996
How to Cite
BOUSQUET, E., MARRAZZO, A., PUGLISI, G., SPADARO, A. and TIRENDI, S. (1996), Synthesis, Physical Properties, Toxicological Studies and Bioavailability of L-Pyroglutamic and L-Glutamic Acid Esters of Paracetamol as Potentially Useful Prodrugs. Journal of Pharmacy and Pharmacology, 48: 479–485. doi: 10.1111/j.2042-7158.1996.tb05958.x
- Issue online: 12 APR 2011
- Version of Record online: 12 APR 2011
- Received September 4, 1995, Accepted January 19, 1996
Paracetamol ester prodrugs with L-pyroglutamic and L-glutamic acid, biosynthetic precursors of glutathione, have been synthesized to reduce paracetamol hepatotoxicity and improve bioavailability.
The toxicological studies of paracetamol esters show that only L-5-oxo-pyrrolidine-2-paracetamol carboxylate reduces toxicity after administration of an overdose. The glutathione hepatic values in mice obtained by intraperitoneal injection of the ester are superimposable on controls and the oral LD50 was found to be greater than 2000 mg kg−1 and the intraperitoneal LD50 was 1900 mg kg−1.
These results taken together with hydrolysis and bioavailability data show that ester is a potential candidate as a prodrug of paracetamol.