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Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat
Article first published online: 21 DEC 2011
DOI: 10.1111/j.2042-7158.2011.01429.x
© 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society
Additional Information
How to Cite
Graham, H., Walker, M., Jones, O., Yates, J., Galetin, A. and Aarons, L. (2012), Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat. Journal of Pharmacy and Pharmacology, 64: 383–396. doi: 10.1111/j.2042-7158.2011.01429.x
Publication History
- Issue published online: 6 FEB 2012
- Article first published online: 21 DEC 2011
- Received February 3, 2011; Accepted November 17, 2011
- Abstract
- Article
- References
- Supporting Information
- Cited By
Table S1 In-vitro data for use as input parameters in models used to predict Kp values in the rat
Table S2 Rat tissue composition data for use as input parameters in models used to predict Kp values
Table S3 Rat Kp predicted via six published equations followed by experimentally determined Kp
Table S4 Rat Vss (L/kg) predicted via four Kp prediction methods and by experimental Kps, followed by experimentally determined Vss (L/kg)
| Filename | Format | Size | Description |
|---|---|---|---|
| JPHP_1429_sm_Tables.doc | 1548K | Supporting info item |
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