Hydroxypropylmethylcellulose films for the ophthalmic delivery of diclofenac sodium

Authors

  • Salah El-Sousi,

    1. Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Al Azhar University, Gaza, Palestine
    Search for more papers by this author
  • Amparo Nácher,

    Corresponding author
    1. Molecular Recognition and Technological Development (IDM), Polytechnic University-University of Valencia, Valencia, Spain
    • Department Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia
    Search for more papers by this author
  • Carla Mura,

    1. Department Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia
    2. Molecular Recognition and Technological Development (IDM), Polytechnic University-University of Valencia, Valencia, Spain
    Search for more papers by this author
  • Ana Catalán-Latorre,

    1. Department Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia
    2. Molecular Recognition and Technological Development (IDM), Polytechnic University-University of Valencia, Valencia, Spain
    Search for more papers by this author
  • Virginia Merino,

    1. Department Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia
    2. Molecular Recognition and Technological Development (IDM), Polytechnic University-University of Valencia, Valencia, Spain
    Search for more papers by this author
  • Matilde Merino-Sanjuán,

    1. Department Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia
    2. Molecular Recognition and Technological Development (IDM), Polytechnic University-University of Valencia, Valencia, Spain
    Search for more papers by this author
  • Octavio Díez-Sales

    1. Department Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Burjassot, Valencia
    2. Molecular Recognition and Technological Development (IDM), Polytechnic University-University of Valencia, Valencia, Spain
    Search for more papers by this author

Correspondence

Amparo Nácher, Av. Vicente Andrés s/n, 46100 Burjassot, Valencia, Spain.

E-mail: amparo.nacher@uv.es

Abstract

Objectives

The aim of this study was to prepare diclofenac/hydroxypropylmethylcellulose (HPMC) and diclofenac-loaded nanoparticles/HPMC films as potential systems for ocular delivery.

Methods

Two different concentration of the polymer were used: 1.5 and 2.0% w/v. Chitosan–hyaluronic acid nanoparticles were prepared by the ionotropic gelation technique. Nanoparticles were characterized by transmission electron microscopy, dynamic light scattering, drug encapsulation efficiency and rheological studies. In-vitro drug studies and corneal penetration release studies were carried out. Drug release mechanism was finally evaluated by fitting the Ritger and Peppas equation to data. In addition corneal hydration level was calculated to determine whether films could damage the corneas.

Key findings

Diclofenac HPMC films presented a faster drug release and a higher drug penetration than nanoparticles; on the contrary nanoparticles containing films were able to give a more sustained release of the drug and thus a slower diclofenac permeation through the cornea than HPMC films.

Conclusions

Nanoparticles loaded with diclofenac sodium in HPMC films may be a valuable alternative for the treatment of ocular inflammatory diseases, since these formulations offer the benefit of sustained releasing directly to the site of action.

Ancillary