Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model
Article first published online: 11 OCT 2012
© 2012 The Authors. JPP © 2012. Royal Pharmaceutical Society
Journal of Pharmacy and Pharmacology
Volume 65, Issue 2, pages 230–235, February 2013
How to Cite
Petersen, S. B., Nielsen, F. S., Ribel, U., Sturis, J. and Skyggebjerg, O. (2013), Comparison of the pharmacokinetics of three concentrations of insulin aspart during continuous subcutaneous insulin infusion (CSII) in a pig model. Journal of Pharmacy and Pharmacology, 65: 230–235. doi: 10.1111/j.2042-7158.2012.01596.x
- Issue published online: 26 DEC 2012
- Article first published online: 11 OCT 2012
- Manuscript Accepted: 30 AUG 2012
- Manuscript Received: 26 APR 2012
- basal rate;
- insulin aspart;
The aim of the study was to investigate the pharmacokinetic properties of insulin aspart (IAsp) in three different concentrations given as a continuous subcutaneous insulin infusion (CSII).
A randomized cross-over study was performed in pigs, where IAsp U200, U100 or U20 was given for 8 h with the same total dose. Six pigs were included and blood was sampled during the CSII and 3 h after.
The half-life (t1/2) was 24.3 (range 17.3–41.3), 28.8 (range 19.6–54.3) and 23.6 (range 17.4–36.8) min for U200, U100 and U20, respectively. The area under the curve per dose (AUC/D) was determined to be 51.2 ± 19.5, 52.3 ± 12.5 and 51.6 ± 6.7 pm × min/kg for U200, U100 and U20, respectively. The steady state plasma concentration (Css) was 57.5 ± 27.1, 54.3 ± 10.3 and 55.1 ± 8.0 pm (mean ± SD) for U200, U100 and U20, respectively. Time to steady state (Tss) was 110 ± 36, 98 ± 48 and 90 ± 27 min for U200, U100 and U20, respectively.
In conclusion, no significant difference was found in t1/2, AUC/D, Css or Tss between the three IAsp concentrations when given at a basal rate in CSII.