SEARCH

SEARCH BY CITATION

References

  • Adamopoulos S, Parissis J, Karatzas D, Kroupis C, Georgiadis M, Karavolias G et al. (2002) Physical training modulates proinflammatory cytokines and the soluble fas/soluble fas ligand system in patients with chronic heart failure. J Am Coll Cardiol 39, 653663.
  • Adams MR, McCredie R, Jessup W, Robinson J, Sullivan D & Celermajer DS. (1997) Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis 129, 261269.
  • Alfieri AB, Briceno L, Fragasso G, Spoladore R, Palloshi A, Bassanelli G et al. (2008) Differential long-term effects of carvedilol on proinflammatory and antiinflammatory cytokines, asymmetric dimethylarginine, and left ventricular function in patients with heart failure. J Cardiovasc Pharmacol 52, 4954.
  • Angulo J, Wright HM, Cuevas P, González-Corrochano R, Fernández A, Cuevas B et al. (2010) Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling. J Sex Med 7, 26812697.
  • Apostolo A, Vignati C, Brusoni D, Cattadori G, Contini M, Veglia F et al. (2009) Erectile dysfunction in heart failure: correlation with severity, exercise performance, comorbidities, and heart failure treatment. J Sex Med 6, 27952805.
  • Atkeson A, Yeh SY, Malhotra A & Jelic S. (2009) Endothelial function in obstructive sleep apnea. Prog Cardiovasc Dis 51, 351362.
  • Averbeck MA, Colares C, de Lira GH, Selbach T & Rhoden EL. (2012) Evaluation of endothelial function with brachial artery ultrasound in men with or without erectile dysfunction and classified as intermediate risk according to the Framingham score. J Sex Med 9, 849856.
  • Ayta IA, McKinlay JB & Krane RJ. (1999) The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 84, 5056.
  • Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB & Rimm EB. (2003) Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 139, 161168.
  • Bandini E, Fisher AD, Corona G, Ricca V, Monami M, Boddi V et al. (2010) Severe depressive symptoms and cardiovascular risk in subjects with erectile dysfunction. J Sex Med 7, 34773486.
  • Barton M, Baretella O & Meyer MR. (2012) Obesity and risk of vascular disease: importance of endothelium-derived vasoconstriction. Br J Pharmacol 165, 591602.
  • Basile A, Maccherini M, Diciolla F, Balistreri A, Bouklas D, Lisi G et al. (2001) Sexual disorders after heart transplantation. Transplant Proc 33, 19171919.
  • Batty GD, Li Q, Czernichow S, Neal B, Zoungas S, Huxley R et al. ; ADVANCE Collaborative Group (2010) Erectile dysfunction and later cardiovascular disease in men with type 2 diabetes: prospective cohort study based on the ADVANCE (action in diabetes and vascular disease: preterax and diamicron modified-release controlled evaluation) trial. J Am Coll Cardiol 56, 19081913.
  • Baumhäkel M & Böhm M. (2007) Erectile dysfunction correlates with left ventricular function and precedes cardiovascular events in cardiovascular high-risk patients. Int J Clin Pract 61, 361366.
  • Belardinelli R, Georgiou D, Cianci G & Purcaro A. (1996) Effects of exercise training on left ventricular filling at rest and during exercise in patients with ischemic cardiomyopathy and severe left ventricular systolic dysfunction. Am Heart J 132, 6170.
  • Bocchi EA, Guimaraes G, Mocelin A, Bacal F, Bellotti G & Ramires JF. (2002) Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: a double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction. Circulation 106, 10971103.
  • Bocchio M, Desideri G, Scarpelli P, Necozione S, Properzi G, Spartera C et al. (2004) Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. J Urol 171, 16011604.
  • Bode-Böger SM, Böger RH, Alfke H, Heinzel D, Tsikas D, Creutzig A et al. (1996) L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation 93, 8590.
  • Böhm M, Baumhäkel M, Teo K, Sleight P, Probstfield J, Gao P et al. ; ONTARGET/TRANSCEND Erectile Dysfunction Substudy Investigators (2010) Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: the ONgoing telmisartan alone and in combination with ramipril global endpoint Trial/Telmisartan randomized assessment study in ACE INtolerant subjects with cardiovascular disease (ONTARGET/TRANSCEND) trials. Circulation 121, 14391446.
  • Brain SD, Williams TJ, Tippins JR, Morris HR & MacIntyre I. (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313, 5456.
  • Braith RW, Welsch MA, Feigenbaum MS, Kluess HA & Pepine CJ. (1999) Neuroendocrine activation in heart failure is modified by endurance exercise training. J Am Coll Cardiol. 34, 11701175.
  • Brixius K, Middeke M, Lichtenthal A, Jahn E & Schwinger RH. (2007) Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men. Clin Exp Pharmacol Physiol. 34, 327331.
  • Bruckert E, Giral P, Heshmati HM & Turpin G. (1996) Men treated with hypolipidaemic drugs complain more frequently of erectile dysfunction. J Clin Pharm Ther 21, 8994.
  • Budweiser S, Enderlein S, Jörres RA, Hitzl AP, Wieland WF, Pfeifer M et al. (2009) Sleep apnea is an independent correlate of erectile and sexual dysfunction. J Sex Med 6, 31473157.
  • Burchardt M, Burchardt T, Baer L, Kiss AJ, Pawar RV, Shabsigh A et al. (2000) Hypertension is associated with severe erectile dysfunction. J Urol 164, 11881191.
  • Burnier M & Brunner HR. (1992) Neurohormonal consequences of diuretics in different cardiovascular syndromes. Eur Heart J 13(Suppl), G:28G:33.
  • Cheitlin MD, Hutter AM Jr, Brindis RG, Ganz P, Kaul S, Russell RO Jr et al. (1999) ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American college of cardiology/American heart association. J Am Coll Cardiol 33, 273282.
  • Chen IJ, Yeh JL, Lo YC, Sheu SH & Lin YT. (1996) Capsinolol: the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart. Br J Pharmacol 119, 714.
  • Chew KK, Bremner A, Stuckey B, Earle C & Jamrozik K. (2009) Is the relationship between cigarette smoking and male erectile dysfunction independent of cardiovascular disease? findings from a population-based cross-sectional study. J Sex Med 6, 222231.
  • Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr et al. (2003) Joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. National heart, lung, and blood institute; national high blood pressure education program coordinating committee. Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 42, 12061252.
  • Cooper TJ, Guazzi M, Al-Mohammad A, Amir O, Bengal T, Cleland JG et al. (2012) Sildenafil in heart failure (SilHF). An investigator-initiated multinational randomized controlled clinical trial: rationale and design. Eur J Heart Fail. Epub ahead of print.
  • Corona G, Monami M, Boddi V, Balzi D, Melani C, Federico N et al. (2010a) Is obesity a further cardiovascular risk factor in patients with erectile dysfunction?. J Sex Med 7, 25382546.
  • Corona G, Monami M, Boddi V, Cameron-Smith M, Fisher AD, de Vita G et al. (2010b) Low testosterone is associated with an increased risk of MACE lethality in subjects with erectile dysfunction. J Sex Med 7, 15571564.
  • Costa C & Virag R. (2009) The endothelial-erectile dysfunction connection: an essential update. J Sex Med 6, 23902404.
  • Cowie MR, Wood DA, Coats AJ, Thompson SG, Poole-Wilson PA, Suresh V et al. (1999) Incidence and aetiology of heart failure; a population-based study. Eur Heart J 20, 421428.
  • Creager MA, Gallagher SJ, Girerd XJ, Coleman SM, Dzau VJ & Cooke JP. (1992) L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 90, 12481253.
  • Croog SH, Levine S, Testa MA, Brown B, Bulpitt CJ, Jenkins CD et al. (1986) The effects of antihypertensive therapy on the quality of life. N Engl J Med 314, 16571664.
  • Dadkhah F, Safarinejad MR, Asgari MA, Hosseini SY, Lashay A & Amini E. (2010) Atorvastatin improves the response to sildenafil in hypercholesterolemic men with erectile dysfunction not initially responsive to sildenafil. Int J Impot Res 22, 5160.
  • Das A, Xi L & Kukreja RC. (2005) Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 280, 1294412955.
  • Davignon J & Ganz P. (2004) Role of endothelial dysfunction in atherosclerosis. Circulation 109, III27III32.
  • Derby CA, Mohr BA, Goldstein I, Feldman HA, Johannes CB & McKinlay JB. (2000) Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?. Urology 56, 302306.
  • Desouza C, Parulkar A, Lumpkin D, Akers D & Fonseca VA. (2002) Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care 25, 13361339.
  • Dessy C, Saliez J, Ghisdal P, Daneau G, Lobysheva II, Frérart F et al. (2005) Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol. Circulation 112, 11981205.
  • Diamond I. (1989) Alcoholic myopathy and cardiomyopathy. N Engl J Med 320, 458460.
  • Do C, Huyghe E, Lapeyre-Mestre M, Montastruc JL & Bagheri H. (2009) Statins and erectile dysfunction: results of a case/non-case study using the French pharmacovigilance system database. Drug Saf 32, 591597.
  • Doğru MT, Başar MM, Simşek A, Yuvanç E, Güneri M, Ebinç H et al. (2008) Effects of statin treatment on serum sex steroids levels and autonomic and erectile function. Urology 71, 703707.
  • Doumas M, Tsakiris A, Douma S, Grigorakis A, Papadopoulos A, Hounta A et al. (2006) Beneficial effects of switching from beta-blockers to nebivolol on the erectile function of hypertensive patients. Asian J Androl 8, 177182.
  • Drexler H, Zeiher AM, Meinzer K & Just H. (1991) Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 338, 15461550.
  • Drory Y, Kravetz S, Florian V & Weingarten M. (1998) Sexual activity after first acute myocardial infarction in middle-aged men: demographic, psychological and medical predictors. Cardiology 90, 207211.
  • Drory Y, Kravetz S & Weingarten M. (2000) Comparison of sexual activity of women and men after a first acute myocardial infarction. Am J Cardiol 85, 12831287.
  • Dusing R. (2003) Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men. Blood Press Suppl 2, 2934.
  • Egashira K, Hirooka Y, Kuga T, Mohri M & Takeshita A. (1996) Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. Circulation 94, 130134.
  • Eliasson K, Lins LE & Rossner S. (1981) Serum lipoprotein changes during atenolol treatment of essential hypertension. Eur J Clin Pharmacol 20, 335338.
  • Eriksson JW, Jansson PA, Carlberg B, Hägg A, Kurland L, Svensson MK et al. (2008) Hydrochlorothiazide, but not candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation: the mechanisms for the diabetes preventing effect of candesartan (MEDICA) study. Hypertension 52, 10301037.
  • Esposito K, Giugliano F, Martedì E, Feola G, Marfella R, D'Armiento M et al. (2005) High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 28, 12011203.
  • Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ & McKinlay JB. (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol 151, 5461.
  • Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB et al. (2000) Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 30, 328338.
  • Ferrari P, Rosman J & Weidmann P. (1991) Antihypertensive agents, serum lipoproteins and glucose metabolism. Am J Cardiol 67, 26B35B.
  • Ferri C, Desideri G, Valenti M, Bellini C, Pasin M, Santucci A et al. (1999) Upregulation of endothelial adhesion molecules in obese hypertensive men. Hypertension 34, 568573.
  • Flather MD, Shibata MC, Coats AJ, Van Veldhuisen DJ, Parkhomenko A, Borbola J et al. (2005) Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 26, 215225.
  • Flynn KE, Piña IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ et al. ; HF-ACTION Investigators (2009) Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301, 14511459.
  • Fogari R, Zoppi A, Poletti L, Marasi G, Mugellini A & Corradi L. (2001) Sexual activity in hypertensive men treated with valsartan or carvedilol: a crossover study. Am J Hypertens 14, 2731.
  • Fragasso G, Palloshi A, Piatti PM, Monti L, Rossetti E, Setola E et al. (2004) Nitric-oxide mediated effects of transdermal capsaicin patches on the ischemic threshold in patients with stable coronary disease. J Cardiovasc Pharmacol 44, 340347.
  • Fragasso G, Salerno A & Margonato A. (2008) Heart rate reduction is probably not the main beneficial mechanism by which beta blockade improves outcome in patients with systolic chronic heart failure. Am J Cardiol 102, 506507.
  • Fragasso G, Spoladore R, Maranta F, Corti A, Lattuada G, Colombo B et al. (2013) Increased low-grade inflammation is associated with lack of functional response to carvedilol in patients with systolic heart failure. J Cardiovasc Med 14, 4956.
  • Franco-Cereceda A & Liska J. (2000) Potential of calcitonin gene-related peptide in coronary heart disease. Pharmacology 60, 18.
  • Freitas AF Jr, Bacal F, Oliveira Jde L Jr , Santos RH, Moreira LF, Silva CP et al. (2009) Impact of sublingual sildenafil on pulmonary hypertension in patients with heart failure. Arq Bras Cardiol 92, 116126.
  • Fung MM, Bettencourt R & Barrett-Connor E. (2004) Heart disease risk factors predict erectile dysfunction 25 years later: the rancho bernardo study. J Am Coll Cardiol 43, 14051411.
  • Galiè N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D et al. (2005) Sildenafil use in pulmonary arterial hypertension (SUPER) study group. sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 353, 21482157.
  • Gentile V, Antonini G, Antonella Bertozzi M, Dinelli N, Rizzo C, Ashraf Virmani M et al. (2009) Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. Curr Med Res Opin 25, 22232228.
  • Ghio S, Gavazzi A, Campana C, Inserra C, Klersy C, Sebastiani R et al. (2001) Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. J Am Coll Cardiol 37, 183188.
  • Giugliano D, Marfella R, Coppola L, Verrazzo G, Acampora R, Giunta R et al. (1997) Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. evidence for reduced availability of nitric oxide during hyperglycemia. Circulation 95, 17831790.
  • Giuliano FA, Leriche A, Jaudinot EO & de Gendre AS. (2004) Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both. Urology 64, 11961201.
  • Gottlieb SS, Khatta M, Friedmann E, Einbinder L, Katzen S, Baker B et al. (2004) The influence of age, gender, and race on the prevalence of depression in heart failure patients. J Am Coll Cardiol 43, 15421549.
  • de Graaf L, Brouwers AH & Diemont WL. (2004) Is decreased libido associated with the use of HMG-CoA-reductase inhibitors? Br J Clin Pharmacol 58, 326328.
  • Grassi G, Seravalle G, Dell'Oro R, Trevano FQ, Bombelli M, Scopelliti F et al. ; CROSS Study (2003) Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: results of the CROSS study. J Hypertens 21, 17611769.
  • Gratzke C, Angulo J, Chitaley K, Dai YT, Kim NN et al. (2010) Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 7, 445475.
  • Grimm RH Jr, Grandits GA, Prineas RJ, McDonald RH, Lewis CE, Flack JM et al. (1997) Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. treatment of mild hypertension study (TOMHS). Hypertension 29, 814.
  • Grover SA, Lowensteyn I, Kaouache M, Marchand S, Coupal L, DeCarolis E et al. (2006) The prevalence of erectile dysfunction in the primary care setting: importance of risk factors for diabetes and vascular disease. Arch Intern Med 166, 213219.
  • Guazzi M, Vicenzi M, Arena R & Guazzi MD. (2011) PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circ Heart Fail 4, 817.
  • Guo W, Liao C, Zou Y, Li F, Li T, Zhou Q et al. (2010) Erectile dysfunction and risk of clinical cardiovascular events: a meta-analysis of seven cohort studies. J Sex Med 7, 28052816.
  • Gupta AK, Dahlof B, Dobson J, Sever PS, Wedel H & Poulter NR; Anglo-Scandinavian Cardiac Outcomes Trial Investigators (2008) Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the anglo-scandinavian cardiac outcomes trial–blood pressure lowering arm and the relative influence of antihypertensive medication. Diabetes Care 31, 982988.
  • Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J, Walther C et al. (2000a) Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: a randomized trial. JAMA 283, 30953101.
  • Hambrecht R, Hilbrich L, Erbs S, Gielen S, Fiehn E, Schoene N et al. (2000b) Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation. J Am Coll Cardiol 35, 706713.
  • Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E et al. (2007) Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol 27, 26502656.
  • Hannan JL, Blaser MC, Oldfield L, Pang JJ, Adams SM, Pang SC et al. (2010) Morphological and functional evidence for the contribution of the pudendal artery in aging-induced erectile dysfunction. J Sex Med 7, 33733384.
  • Hannan JL, Blaser MC, Pang JJ, Adams SM, Pang SC & Adams MA. (2011) Impact of hypertension, aging, and antihypertensive treatment on the morphology of the pudendal artery J Sex Med 8, 10271038.
  • Hansson GK, Robertson AK & Soderberg-Naucler C. (2006) Inflammation and atherosclerosis. Annu Rev Pathol 1, 297329.
  • Haykowsky MJ, Liang Y, Pechter D, Jones LW, McAlister FA & Clark AM. (2007) A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: the benefit depends on the type of training performed. J Am Coll Cardiol 49, 23292336.
  • Hebert K, Lopez B, Castellanos J, Palacio A, Tamariz L & Arcement L. (2008) The prevalence of erectile dysfunction in heart failure patients by race and ethnicity. Int J Impot 20, 507511.
  • Hebert K, Lopez B, Macedo FYB, Gomes CR, Urena J & Arcement L. (2009) Peripheral vascular disease and erectile dysfunction as predictors of mortality in heart failure patients. J Sex Med 6, 19992007.
  • Hellerstein HK & Friedman EH. (1970) Sexual activity and the postcoronary patient. Arch Intern Med 125, 987999.
  • Herrmann HC, Levine LA, Macaluso J Jr, Walsh M, Bradbury D, Schwartz S et al. (2006) Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? hypothesis and pilot trial results. J Sex Med 3, 303308.
  • Hodges LD, Kirby M, Solanki J, O'Donnell J & Brodie DA. (2007) The temporal relationship between erectile dysfunction and cardiovascular disease. Int J Clin Pract 61, 20192025.
  • Hua XY & Yaksh TL. (1993) Pharmacology of the effects of bradykinin, serotonin, and histamine on the release of calcitonin gene-related peptide from C-fiber terminals in the rat trachea. J Neurosci 13, 19471953.
  • Huang YC, Ning H, Shindel AW, Fandel TM, Lin G, Harraz AM et al. (2010) The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med 7, 13911400.
  • Jaarsma T, Dracup K, Walden J & Stevenson LW. (1996) Sexual function in patients with advanced heart failure. Heart Lung 25, 262270.
  • Jackson G, Montorsi P & Cheitlin MD. (2006a) Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective. Urology 68, 4760.
  • Jackson G, Rosen RC, Kloner RA & Kostis JB. (2006b) The second princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine. J Sex Med 3, 2836; discussion 36.
  • Jackson G, Montorsi P, Adams MA, Anis T, El-Sakka A, Miner M et al. (2010) Cardiovascular aspects of sexual medicine. J Sex Med 7, 16081626.
  • Jankowska EA, Filippatos G, Ponikowska B, Borodulin-Nadzieja L, Anker SD, Banasiak W et al. (2009) Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. J Card Fail 15, 442450.
  • Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG et al. (2009) Focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American college of cardiology foundation/American heart association task force on practice guidelines: developed in collaboration with the international society for heart and lung transplantation. Circulation 119, 19772016.
  • Kallner G. (1998) Release and effects of calcitonin gene-related peptide in myocardial ischaemia. Scand Cardiovasc J Suppl 49, 135.
  • Kam SC, Chae MR, Kim JY, Choo SH, Han DH & Lee SW. (2010) Effects of ethanol on the tonicity of corporal tissue and the intracellular Ca2+ concentration of human corporal smooth muscle cells. Asian J Androl 12, 890898.
  • Karavitakis M, Komninos C, Theodorakis PN, Politis V, Lefakis G, Mitsios K et al. (2011) Evaluation of sexual function in hypertensive men receiving treatment: a review of current guidelines recommendation. J Sex Med 8, 24052414.
  • Kawasaki H, Takasaki K, Saito A & Goto K. (1988) Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 335, 164167.
  • Khoo J, Piantadosi C, Worthley S & Wittert GA. (2010) Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men. Int J Obes 34, 13961403.
  • Klatsky AL, Friedman GD, Siegelaub AB & Gerard MJ. (1977) Alcohol consumption and blood pressure kaiser-permanente multiphasic health examination data. N Engl J Med 296, 11941200.
  • Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP & Krumholz HM. (2002) Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 288, 351357.
  • Koifman B, Wollman Y, Bogomolny N, Chernichowsky T, Finkelstein A, Peer G et al. (1995) Improvement of cardiac performance by intravenous infusion of L-arginine in patients with moderate congestive heart failure. J Am Coll Cardiol 26, 12511256.
  • Kostis JB, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett AL et al. (2005) Sexual dysfunction and cardiac risk (the second princeton consensus conference). Am J Cardiol 96, 313321.
  • Kupelian V, Shabsigh R, Araujo AB, O'Donnell AB & McKinlay JB. (2006) Erectile dysfunction as a predictor of the metabolic syndrome in aging men: results from the Massachusetts male aging study. J Urol 176, 222226.
  • Laaksonen DE, Niskanen L, Punnonen K, Nyyssönen K, Tuomainen TP, Valkonen VP et al. (2005) The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study. J Clin Endocrinol Metab 90, 712719.
  • Lai YH, Hsieh SR, Ho WC & Chiou AF. (2011) Factors associated with sexual quality of life in patients before and after coronary artery bypass grafting surgery. J Cardiovasc Nurs 26, 487496.
  • Lamina S, Okoye CG & Dagogo TT. (2009) Therapeutic effect of an interval exercise training program in the management of erectile dysfunction in hypertensive patients. J Clin Hypertens 11, 125129.
  • Laumann EO, Paik A & Rosen RC. (1999) Sexual dysfunction in the united states: prevalence and predictors. JAMA 281, 537544.
  • Lavie L. (2009) Oxidative stress–a unifying paradigm in obstructive sleep apnea and comorbidities. Prog Cardiovasc Dis 51, 30312.
  • Lazzeri M, Barbanti G, Beneforti P & Turini D. (1994) Intraurethrally infused capsaicin induces penile erection in humans. Scand J Urol Nephrol 28, 409412.
  • Lepore JJ, Maroo A, Bigatello LM, Dec GW, Zapol WM, Bloch KD et al. (2005) Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest 127, 16471653.
  • Lewis GD, Shah R, Shahzad K, Camuso JM, Pappagianopoulos PP, Hung J et al. (2007) Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation 116, 15551562.
  • Li YJ & Peng J. (2002) The cardioprotection of calcitonin gene-related peptide-mediated preconditioning. Eur J Pharmacol 442, 173177.
  • Libby P, Sukhova G, Lee RT & Galis ZS. (1995) Cytokines regulate vascular functions related to stability of the atherosclerotic plaque. J Cardiovasc Pharmacol 25(Suppl 2), S912.
  • Lithell HO. (1991) Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism. Diabetes Care 14, 203209.
  • Loriaux DL, Menard R, Taylor A, Pita JC & Santen R. (1976) Spironolactone and endocrine dysfunction. Ann Intern Med 85, 630636.
  • Mancini GB, Henry GC, Macaya C, O'Neill BJ, Pucillo AL, Carere RG et al. (1996) Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (trial on reversing ENdothelial dysfunction) study. Circulation 94, 258265.
  • Mannino DM, Klevens RM & Flanders WD. (1994) Cigarette smoking: an independent risk factor for impotence?Am J Epidemiol 140, 10031008.
  • Marcuccilli L, Casida JJ, Peters RM & Wright S. (2011) Sex and intimacy among patients with implantable left-ventricular assist devices. J Cardiovasc Nurs 26, 504511.
  • Maxwell AJ, Zapien MP, Pearce GL, MacCallum G & Stone PH. (2002) Randomized trial of a medical food for the dietary management of chronic, stable angina. J Am Coll Cardiol 39, 3745.
  • Miner M & Billups KL. (2008) Erectile dysfunction and dyslipidemia: relevance and role of phosphodiesterase type-5 inhibitors and statins. J Sex Med 5, 10661078.
  • Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A et al. 2003. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 44, 360364; discussion 364-365.
  • Montorsi P, Ravagnani PM, Galli S, Rotatori F, Veglia F, Briganti A et al. (2006) Association between erectile dysfunction and coronary artery disease. role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. Eur Heart J 27, 26322639.
  • Morelli A, Chavalmane AK, Filippi S, Fibbi B, Silvestrini E, Sarchielli E et al. (2009) Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation. J Sex Med 6, 91106.
  • Nualnim N, Barnes JN, Tarumi T, Renzi CP & Tanaka H. (2011) Comparison of central artery elasticity in swimmers, runners, and the sedentary. Am J Cardiol 107, 783787.
  • Oroszi G, Szilvassy Z, Nemeth J, Tosaki A & Szolcsanyi J. (1999) Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart. Pharmacol Res 40, 125128.
  • Osman R, L'Allier PL, Elgharib N & Tardif JC. (2006) Critical appraisal of C-reactive protein throughout the spectrum of cardiovascular disease. Vasc Health Risk Manag 2, 221237.
  • Ozbek E, Tasci AI, Ilbey YO, Simsek A, Somay A & Metin G. (2010) The effect of regular exercise on penile nitric oxide synthase expression in rats. Int J Androl 33, 623628.
  • Palloshi A, Fragasso G, Piatti P, Monti LD, Setola E, Valsecchi G et al. (2004) Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol 93, 933935.
  • Piatti PM, Monti LD, Galli L, Fragasso G, Valsecchi G, Conti M et al. (2000) Relationship between endothelin-1 concentration and metabolic alterations typical of the insulin resistance syndrome. Metabolism 49, 748752.
  • Piatti P, Fragasso G, Monti LD, Setola E, Lucotti P, Fermo I et al. (2003a) Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels. Circulation 107, 429436.
  • Piatti P, Di Mario C, Monti LD, Fragasso G, Sgura F, Caumo A et al. (2003b) Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation 108, 20742081.
  • Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B et al. (2003) Eplerenone post-acute myocardial infarction heart failure efficacy and survival study investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348, 13091321.
  • Pohjantahti-Maaroos H & Palomaki A. (2011) Comparison of metabolic syndrome subjects with and without erectile dysfunction - levels of circulating oxidised LDL and arterial elasticity. Int J Clin Pract 65, 274280.
  • Potenza MA, Gagliardi S, Nacci C, Carratu' MR & Montagnani M. (2009) Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets. Curr Med Chem 16, 94112.
  • Pourmand G, Alidaee MR, Rasuli S, Maleki A & Mehrsai A. (2004) Do cigarette smokers with erectile dysfunction benefit from stopping?: a prospective study. BJU Int 94, 13101313.
  • Pyorala M, Miettinen H, Laakso M & Pyorala K. (1998) Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the helsinki policemen study. Circulation 98, 398404.
  • Rabe KF, Tenor H, Dent G, Schudt C, Liebig S & Magnussen H. (1993) Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization. Am J Physiol 264, L458464.
  • Raman KG, Gandley RE, Rohland J, Zenati MS & Tzeng E. (2011) Early hypercholesterolemia contributes to vasomotor dysfunction and injury associated atherogenesis that can be inhibited by nitric oxide. J Vasc Surg 53, 754763.
  • Rastogi S, Rodriguez JJ, Kapur V & Schwarz ER. (2005) Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem. Int J Impot Res 17, S25S36.
  • Reape TJ & Groot PH. (1999) Chemokines and atherosclerosis. Atherosclerosis. 147, 213225.
  • Rector TS, Bank AJ, Mullen KA, Tschumperlin LK, Sih R, Pillai K et al. (1996) Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 93, 21352141.
  • Reddy HK, Weber KT, Janicki JS & McElroy PA. (1988) Hemodynamic, ventilatory and metabolic effects of light isometric exercise in patients with chronic heart failure. J Am Coll Cardiol 12, 353358.
  • Rhodes CJ, Davidson A, Gibbs JS, Wharton J & Wilkins MR. (2009) Therapeutic targets in pulmonary arterial hypertension. Pharmacol Ther 121, 6988.
  • Riedner CE, Rhoden EL, Fuchs SC, Wainstein MV, Gonçalves SC, Wainstein RV et al. (2011) Erectile dysfunction and coronary artery disease: an association of higher risk in younger men. J Sex Med 8, 14451453.
  • Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N et al. ; American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2008) Heart disease and stroke statistics–2008 update: a report from the American Heart Association statistics committee and stroke statistics subcommittee. Circulation 117, 25146.
  • Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A & Sand M. (2004) Men's attitudes to life events and sexuality (MALES) study. The multinational men's attitudes to life events and sexuality (MALES) study: I. prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 20, 607617.
  • Roveda F, Middlekauff HR, Rondon MU, Reis SF, Souza M, Nastari L et al. (2003) The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. J Am Coll Cardiol 42, 854860.
  • Salloum FN, Abbate A, Das A, Houser JE, Mudrick CA, Qureshi IZ et al. (2008) Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice. Am J Physiol Heart Circ Physiol 294, H13981406.
  • Saltzman EA, Guay AT & Jacobson J. (2004) Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: a clinical observation. J Urol 172, 255258.
  • Schouten BW, Bohnen AM, Bosch JL, Bernsen RM, Deckers JW, Dohle GR et al. Erectile dysfunction prospectively associated with cardiovascular disease in the dutch general population: results from the Krimpen study. Int J Impot Res 20, 9299 (2008).
  • Schwarz ER, Rastogi S, Kapur V, Sulemanjee N & Rodriguez JJ. (2006) Erectile dysfunction in heart failure patients. J Am Coll Cardiol 48, 11111119.
  • Schwarz ER, Kapur V, Bionat S, Rastogi S, Gupta R & Rosanio S. (2008) The prevalence and clinical relevance of sexual dysfunction in women and men with chronic heart failure. Int J Impot Res 20, 8591.
  • Serrano CV Jr, Setani KT, Sakamoto E, Andrei AM & Fraguas R. (2011) Association between depression and development of coronary artery disease: pathophysiologic and diagnostic implications. Vasc Health Risk Manag 7, 159164.
  • Sighinolfi MC, Mofferdin A, De Stefani S, Micali S, Cicero AF & Bianchi G. (2007) Immediate improvement in penile hemodynamics after cessation of smoking: previous results. Urology 69, 163165.
  • Solomon H, Man JW & Jackson G. (2003) Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 89, 251253.
  • Solomon H, Samarasinghe YP, Feher MD, Man J, Rivas-Toro H, Lumb PJ et al. (2006) Erectile dysfunction and statin treatment in high cardiovascular risk patients. Int J Clin Pract 60, 141145.
  • Somers VK, Dyken ME, Clary MP & Abboud FM. (1995) Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96, 18971904.
  • Speel TG, Kiemeney LA, Thien T, Smits P & Meuleman EJ. (2005) Long-term effect of inhibition of the angiotensin-converting enzyme (ACE) on cavernosal perfusion in men with atherosclerotic erectile dysfunction: a pilot study. J Sex Med 2, 207212.
  • Stellato RK, Feldman HA, Hamdy O, Horton ES & McKinlay JB. (2000) Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care 23, 490494.
  • Suetomi T, Kawai K, Hinotsu S, Joraku A, Oikawa T, Sekido NI et al. (2008) Negative impact of metabolic syndrome on the responsiveness to sildenafil in japanese men. J Sex Med. 5, 14431450.
  • Szymanski FM, Filipiak KJ, Hrynkiewicz-Szymanska A, Grabowski M, Dabrowska-Kugacka A & Opolski G. (2011) The high risk of obstructive sleep apnea-an independent risk factor of erectile dysfunction in ST-segment elevation myocardial infarction patients. J Sex Med. 8, 14341438.
  • Takimoto E, Champion HC, Li M, Belardi D, Ren S, Rodriguez ER et al. (2005) Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med 11, 214222.
  • Tamler R & Bar-Chama N. (2008) Assessment of endothelial function in the patient with erectile dysfunction: an opportunity for the urologist. Int J Impot Res 20, 370377.
  • Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM & Coltman CA. (2005) Erectile dysfunction and subsequent cardiovascular disease. JAMA. 294, 29963002.
  • Thorson AI. (2003) Sexual activity and the cardiac patient. Am J Geriatr Cardiol 12, 3840.
  • Toque HA, da Silva FH, Calixto MC, Lintomen L, Schenka AA, Saad MJ et al. (2011) High-fat diet associated with obesity induces impairment of mouse corpus cavernosum responses. BJU Int 107, 16281634.
  • Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB et al. (1996) Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 93, 704711.
  • Tostes RC, Carneiro FS, Lee AJ, Giachini FR, Leite R, Osawa Y et al. (2008) Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation. J Sex Med 5, 12841295.
  • Urbonaviciene G, Frystyk J, Flyvbjerg A, Urbonavicius S, Henneberg EW & Lindholt JS. (2012) Markers of inflammation in relation to long-term cardiovascular mortality in patients with lower-extremity peripheral arterial disease. Int J Cardiol 160, 8994.
  • Vlachopoulos C, Rokkas K, Ioakeimidis N & Stefanadis C. (2007) Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. Eur Urol 52, 15901600.
  • Vlachopoulos C, Ioakeimidis N, Terentes-Printzios D & Stefanadis C. (2008) The triad: erectile dysfunction–endothelial dysfunction–cardiovascular disease. Curr Pharm Des 14, 37003714.
  • Walsh T. (2009) Impaired endothelial nitric oxide bioavailability: a common link between aging, hypertension, and atherogenesis?. J Am Geriatr Soc 57, 140145.
  • Webster LJ, Michelakis ED, Davis T & Archer SL. (2004) Use of sildenafil for safe improvement of erectile function and quality of life in men with New York heart association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial. Arch Intern Med 164, 514520.
  • Wehr E, Pilz S, Boehm BO, Marz W, Grammer T & Obermayer-Pietsch B. (2011) Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail 13, 4828.
  • Whelton PK, Barzilay J, Cushman WC, Davis BR, Iiamathi E, Kostis JB et al. ; ALLHAT Collaborative Research Group (2005) Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). Arch Intern Med 165, 14011409.
  • White CB, Roberts AM & Joshua IG. (1993) Arteriolar dilation mediated by capsaicin and calcitonin gene-related peptide in rats. Am J Physiol 265, H14111415.
  • Wilkens H, Guth A, König J, Forestier N, Cremers B, Hennen B et al. (2001) Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 104, 12181222.
  • Wu C, Zhang H, Gao Y, Tan A, Yang X, Lu Z et al. (2011) The association of smoking and erectile dysfunction: results from the Fangchenggang area male health and examination survey (FAMHES). J Androl 33, 5965.
  • Yndestad A, Damas JK, Oie E, Ueland T, Gullestad L & Aukrust P. (2006) Systemic inflammation in heart failure–the whys and wherefores. Heart Fail Rev 11, 8392.
  • Zhou MS, Schulman IH, Jaimes EA & Raij L. (2008) Thiazide diuretics, endothelial function, and vascular oxidative stress. J Hypertens 26, 494500.
  • Zouaoui Boudjeltia K, Roumeguere T, Delree P, Moguilevsky N, Ducobu J, Vanhaeverbeek M et al. (2007) Presence of LDL modified by myeloperoxidase in the penis in patients with vascular erectile dysfunction: a preliminary study. Eur Urol 51, 262268; discussion 268-269.