Associations between aggressive behaviour scores and cardiovascular risk factors in childhood

Authors

  • S. Louise,

    Corresponding author
    • Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Crawley, Australia
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  • N. M. Warrington,

    1. Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Crawley, Australia
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  • P. A. McCaskie,

    1. Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Crawley, Australia
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  • W. H. Oddy,

    1. Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Crawley, Australia
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  • S. R. Zubrick,

    1. Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Crawley, Australia
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  • B. Hands,

    1. University of Notre Dame, Fremantle, Australia
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  • T. A. Mori,

    1. School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia
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  • L. Briollais,

    1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
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  • S. Silburn,

    1. Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Crawley, Australia
    2. Developmental Health and Education Research, Menzies School of Health Research, Darwin, Australia
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  • L. J. Palmer,

    1. Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Crawley, Australia
    2. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    3. Dalla Lana School of Public Health, University of Toronto and Cancer Care Ontario, Toronto, Canada
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  • E. Mattes,

    1. Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Crawley, Australia
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    • Provided equal last author contributions to this paper.
  • L. J. Beilin

    1. School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia
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    • Provided equal last author contributions to this paper.

Address for correspondence: Miss S Louise, Centre for Genetic Epidemiology and Biostatistics, The University of Western Australia, Mailbag: M409, 35 Stirling Hwy, Crawley, WA 6009, Australia. E-mail: slouise@meddent.uwa.edu.au

Summary

Objective

To examine the influence of aggressive behaviour scores on cardiovascular disease (CVD) risk factors throughout childhood.

Methods

This study utilized cross-sectional and longitudinal data from the Western Australian Pregnancy Cohort (Raine) Study (n = 2900). Aggressive behaviour scores were derived from the Child Behavior Checklist/4–18(CBCL), Youth Self-Report/11–18 (YSR) and Teacher Report Form/6–18 (TRF). CVD risk factors included body mass index (BMI), blood pressure, fasting lipids and homeostasis model of insulin resistance (HOMA-IR).

Results

Girls with higher aggressive behaviour scores had higher BMI from 10 years of age (P ≤ 0.001), higher BMI trajectories throughout childhood (P = 0.0003) and at 14 years higher HOMA-IR (P = 0.008). At the 14-year survey, this equated to a difference of 1.7 kg/m2 in the predicted BMI between the extreme CBCL scores in girls (top 5% (CBCL ≥ 17) vs. CBCL score = 0). Boys with higher aggressive behaviour scores had higher BMI at 5 years (P = 0.002), lower diastolic pressure at 14 years (P = 0.002) and lower systolic blood pressure trajectories throughout childhood (P = 0.016).

Conclusion

Aggressive behaviour influences BMI from early childhood in girls but not boys. If this association is causal, childhood offers the opportunity for early behavioural intervention for obesity prevention.

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