Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development
Article first published online: 31 AUG 2012
© 2012 The Authors. Pediatric Obesity © 2012 International Association for the Study of Obesity
Volume 7, Issue 6, pages 453–460, December 2012
How to Cite
Hohmann, S., Buchmann, A. F., Witt, S. H., Rietschel, M., Jennen-Steinmetz, C., Schmidt, M. H., Esser, G., Banaschewski, T. and Laucht, M. (2012), Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development. Pediatric Obesity, 7: 453–460. doi: 10.1111/j.2047-6310.2012.00069.x
- Issue published online: 9 NOV 2012
- Article first published online: 31 AUG 2012
- Manuscript Accepted: 1 MAY 2012
- Manuscript Revised: 26 MAR 2012
- Manuscript Received: 22 NOV 2011
- German Research Foundation (DFG)
- Federal Ministry for Education and Research
- neuropeptide Y;
- weight regulation.
- NPY serves as a potent orexigenic signal and plays an important role in body weight regulation. Recently, evidence for the impact of NPY gene variation on body weight regulation and risk of obesity was provided.
- Research has indicated that genetic influences on some traits such as BMI change with age, with often showing a stronger effect as children mature.
- We show first evidence from a longitudinal study, demonstrating an association between NPY rs16147 genotype and BMI development from infancy into young adulthood.
- The NPY effect appears to increase with age, being more pronounced in older age groups than in younger ones.
To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood.
Longitudinal, prospective study of a German community sample.
n = 306 young adults (139 males, 167 females).
Participants’ body weight and height were assessed at the ages of 3 months and 2, 4.5, 8, 11, 15 and 19 years. NPY rs16147 was genotyped.
Controlling for a number of possible confounders, homozygote carriers of the rs16147 C allele exhibited significantly lower BMI scores when compared with individuals carrying the T allele. In addition, a significant genotype by age interaction emerged, indicating that the genotype effect increased during the course of development.
This is the first longitudinal study to report an association between rs16147 and BMI during childhood and adolescence. The finding that this effect increased during the course of development may either be due to age-dependent alterations in gene expression or to maturation processes within the weight regulation circuits of the central nervous system.