Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers
Article first published online: 19 SEP 2012
© 2012 The Authors. Pediatric Obesity © 2012 International Association for the Study of Obesity
Volume 7, Issue 6, pages e86–e89, December 2012
How to Cite
Francescato, G., Agosti, M., Bedogni, G., Pastò, E., Melzi d'Eril, G., Barassi, A., Risè, P. and Agostoni, C. (2012), Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. Pediatric Obesity, 7: e86–e89. doi: 10.1111/j.2047-6310.2012.00097.x
- Issue published online: 9 NOV 2012
- Article first published online: 19 SEP 2012
- Manuscript Accepted: 27 JUL 2012
- Manuscript Revised: 16 JUL 2012
- Manuscript Received: 18 DEC 2011
- Docosahexaenoic acid;
- gestational diabetes;
- retinol-binding protein
Biochemical predictors of infants' growth changes are not available.
We tested whether retinol-binding protein (RBP), docosahexaenoic acid and insulin (I) measured within 72 h from birth are associated with growth changes in infants born to mothers with gestational diabetes mellitus (GDM).
Fifty-six children, 32 born to diabetic mothers treated with insulin (GDM-I) and 24 born to diabetic mothers treated with diet (GDM-D), were evaluated at 0, 1, 3, 6 and 12 months of life.
At multivariable regression performed using generalized estimating equations, early RBP levels and maternal body mass index were associated to average weight changes and early RBP and insulin levels to average length changes, respectively. There was no difference between GDM-I and GDM-D infants.
This exploratory study suggests that early RBP levels may be a predictor of growth changes.