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Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers

Authors


Address for correspondence: Professor Carlo Agostoni, Institute of Pediatrics, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Via Della Commenda 9, 20121 Milano, Italy. E-mail: carlo.agostoni@unimi.it

Summary

Background

Biochemical predictors of infants' growth changes are not available.

Objectives

We tested whether retinol-binding protein (RBP), docosahexaenoic acid and insulin (I) measured within 72 h from birth are associated with growth changes in infants born to mothers with gestational diabetes mellitus (GDM).

Methods

Fifty-six children, 32 born to diabetic mothers treated with insulin (GDM-I) and 24 born to diabetic mothers treated with diet (GDM-D), were evaluated at 0, 1, 3, 6 and 12 months of life.

Results

At multivariable regression performed using generalized estimating equations, early RBP levels and maternal body mass index were associated to average weight changes and early RBP and insulin levels to average length changes, respectively. There was no difference between GDM-I and GDM-D infants.

Conclusions

This exploratory study suggests that early RBP levels may be a predictor of growth changes.

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