• 1
    Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006; 295: 15491555.
  • 2
    Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999; 103(6 Pt 1): 11751182.
  • 3
    Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005; 116: 473480.
  • 4
    Clark LT, El-Atat F. Metabolic syndrome in African Americans: implications for preventing coronary heart disease. Clin Cardiol 2007; 30: 161164.
  • 5
    Cossrow N, Falkner B. Race/ethnic issues in obesity and obesity-related comorbidities. J Clin Endocrinol Metab 2004; 89: 25902594.
  • 6
    Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005; 54: 16151625.
  • 7
    Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 2004; 279: 4235142354.
  • 8
    Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 17521761.
  • 9
    Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, Desouza CA. Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity 2006; 14: 21272131.
  • 10
    Araki S, Dobashi K, Yamamoto Y, Asayama K, Kusuhara K. Increased plasma isoprostane is associated with visceral fat, high molecular weight adiponectin, and metabolic complications in obese children. Eur J Pediatr 2010; 169: 965970.
  • 11
    Kelly AS, Steinberger J, Kaiser DR, Olson TP, Bank AJ, Dengel DR. Oxidative stress and adverse adipokine profile characterize the metabolic syndrome in children. J Cardiometab Syndr 2006; 1: 248252.
  • 12
    Oliver SR, Rosa JS, Milne GL, et al. Increased oxidative stress and altered substrate metabolism in obese children. Int J Pediatr Obes 2010; 5: 436444.
  • 13
    Sinaiko AR, Steinberger J, Moran A, et al. Relation of body mass index and insulin resistance to cardiovascular risk factors, inflammatory factors, and oxidative stress during adolescence. Circulation 2005; 111: 19851991.
  • 14
    Stringer DM, Sellers EA, Burr LL, Taylor CG. Altered plasma adipokines and markers of oxidative stress suggest increased risk of cardiovascular disease in First Nation youth with obesity or type 2 diabetes mellitus. Pediatr Diabetes 2009; 10: 269277.
  • 15
    Ustundag B, Gungor S, Aygun AD, Turgut M, Yilmaz E. Oxidative status and serum leptin levels in obese prepubertal children. Cell Biochem Funct 2007; 25: 479483.
  • 16
    Codoñer-Franch P, Boix-García L, Simó-Jordá R, del Castillo-Villaescusa C, Maset-Maldonado J, Valls-Bellés V. Is obesity associated with oxidative stress in children? Int J Pediatr Obes 2010; 5: 5663.
  • 17
    Ostrow V, Wu S, Aguilar A, Bonner R, Jr, Suarez E, De Luca F. Association between oxidative stress and masked hypertension in a multi-ethnic population of obese children and adolescents. J Pediatr 2011; 158: 628633 e621.
  • 18
    Hoffman RP. Metabolic syndrome racial differences in adolescents. Curr Diabetes Rev 2009; 5: 259265.
  • 19
    Sumner AE. Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults. J Pediatr 2009; 155: S7 e7–e11.
  • 20
    CDC. National Health and Nutrition Examination: Anthropometry Procedures Manual. US Department of Health and Human Services, Centers for Disease Control and Prevention: Hyattsville, MD, 2009.
  • 21
    Centers for Disease Control and Prevention, National Center for Health Statistics. CDC growth charts: United States. [WWW document]. URL (accessed 30 May 2000).
  • 22
    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114(2 Suppl. 4th Report): 555576.
  • 23
    Bruce RA. Exercise testing of patients with coronary heart disease. Principles and normal standards for evaluation. Ann Clin Res 1971; 3: 323332.
  • 24
    Morrow JD, Zackert WE, Yang JP, et al. Quantification of the major urinary metabolite of 15-F2t-Isoprostane (8-iso-PGF2α) by a stable isotope dilution mass spectrometric assay. Anal Biochem 1999; 269: 326331.
  • 25
    Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412419.
  • 26
    Donahue R, Jacobs DR, Jr, Sidney S, Wagenkneckt L, Albers J, Hunley S. Distribution of lipoproteins and apolipoproteins in young adults: the CARDIA Study. Arteriosclerosis 1989; 9: 656664.
  • 27
    Sumner A, Cowie CC. Ethnic differences in the ability of triglyceride levels to identify insulin resistance. Atherosclerosis 2008; 196: 696703.
  • 28
    Srinivasan SR, Frerichs R, Webber L, Berenson GS. Serum lipoprotein profile in children from a biracial commnity: the Bogalusa Heart Study. Circulation 1976; 54: 309318.
  • 29
    Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third national health and nutrition examination survery, 1988–1994. Arch Pediatr Adolesc Med 2003; 157: 821827.
  • 30
    Yu SSK, Castillo DC, Courville AB, Sumner AE. The triglyceride paradox in people of African descent. Metab Syndr Relat Disord 2012; 10: 7782.
  • 31
    Stein E, Kushner H, Gidding S, Falkner B. Plasma lipid concentrations in nondiabetic African American adults: associations with insulin resistance and the metabolic syndrome. Metabolism 2007; 56: 954960.
  • 32
    Rodrigo R, Prat H, Passalacqua W, Araya J, Guichard C, Bachler J. Relationship between oxidative stress and essential hypertension. Hypertens Res 2007; 30: 11591167.
  • 33
    Grossman E. Does increased oxidative stress cause hypertension? Diabetes Care 2008; 31(Suppl. 2): S185S189.
  • 34
    Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care 2008; 31(Suppl. 2): S181S184.
  • 35
    Cruz ML, Huang TT, Johnson MS, Gower BA, Goran MI. Insulin sensitivity and blood pressure in black and white children. Hypertension 2002; 40: 1822.
  • 36
    Giannini C, de Giorgis T, Scarinci A, et al. Increased carotid intima-media thickness in pre-pubertal children with constitutional leanness and severe obesity: the speculative role of insulin sensitivity, oxidant status, and chronic inflammation. Eur J Endocrinol 2009; 161: 7380.
  • 37
    Schwedhelm E, Bartling A, Lenzen H, et al. Urinary 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease: a matched case-control study. Circulation 2004; 109: 843848.
  • 38
    Clasey JL, Bouchard C, Teates CD, et al. The use of anthropometric and dual-energy X-ray absorptiometry (DXA) measures to estimate total abdominal and abdominal visceral fat in men and women. Obes Res 1999; 7: 256264.
  • 39
    Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976; 15: 212216.
  • 40
    Davalos A, Gomez-Cordoves C, Bartolome B. Extending applicability of the oxygen radical absorbance capacity (ORAC-fluorescein) assay. J Agric Food Chem 2004; 52: 4854.
  • 41
    Apak R, Guclu K, Ozyurek M, Bektasoglu B, Bener M. Cupric ion reducing antioxidant capacity assay for antioxidants in human serum and for hydroxyl radical scavengers. Methods Mol Biol 2010; 594: 215239.
  • 42
    Morrow JD, Hill KE, Burk RF, Nammour TM, Badr KF, Roberts LJ, II. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 1990; 87: 93839387.
  • 43
    Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ. Isoprostane generation and function. Chem Rec 2011; 111: 59735996.
  • 44
    Kadiiska MB, Gladen BC, Baird DD, et al. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med 2005; 38: 698710.
  • 45
    Shaibi GQ, Davis JN, Weigensberg MJ, Goran MI. Improving insulin resistance in obese youth: choose your measures wisely. Int J Pediatr Obes 2011; 6: e290e296.
  • 46
    Gungor N, Saad R, Janosky J, Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr 2004; 144: 4755.
  • 47
    Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005; 115: e500e503.
  • 48
    Levy-Marchal C, Arslanian S, Cutfield W, et al. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab 2010; 95: 51895198.
  • 49
    d'Annunzio G, Vanelli M, Pistorio A, et al. Insulin resistance and secretion indexes in healthy Italian children and adolescents: a multicentre study. Acta Biomed 2009; 80: 2128.
  • 50
    Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents: a validation study. Diabetes Care 2004; 27: 314319.
  • 51
    Adam TC, Hasson RE, Lane CJ, et al. Fasting indicators of insulin sensitivity: effects of ethnicity and pubertal status. Diabetes Care 2011; 34: 994999.