A common variant in the FTO locus is associated with waist–hip ratio in Indian adolescents
Article first published online: 28 FEB 2013
© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity
How to Cite
Vasan, S. K., Fall, T., Job, V., Gu, H. F., Ingelsson, E., Brismar, K., Karpe, F. and Thomas, N. (2013), A common variant in the FTO locus is associated with waist–hip ratio in Indian adolescents. Pediatric Obesity. doi: 10.1111/j.2047-6310.2013.00118.x
- Article first published online: 28 FEB 2013
- Manuscript Accepted: 15 OCT 2012
- Manuscript Revised: 4 OCT 2012
- Manuscript Received: 16 MAR 2012
- Family Erling-Persson Foundation
- waist–hip ratio
Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined.
To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.
Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India.
The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313.
The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood.