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A common variant in the FTO locus is associated with waist–hip ratio in Indian adolescents

Authors


Address for correspondence: Dr SK Vasan, Rolf Luft Research Centre for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska University Hospital, L1:01, 171 76 Stockholm, Sweden. E-mail: vasan.kandaswamy@ki.se, Dr. N Thomas, Department of Endocrinology, Diabetes & Metabolism, Christian Medical College & Hospital, Vellore-632004. India. E-mail: nihal_thomas@yahoo.com

Summary

Background

Common variants in the FTO locus, and near MC4R locus, have been shown to have a robust association with obesity in children and adults among various ethnic groups. Associations with obesity traits among Indian adolescents have not been determined.

Objective

To study the association of rs9939609 (FTO) and rs17782313 (MC4R) to obesity related anthropometric traits in Indian adolescents.

Methods

Subjects for the current study were recruited from a cross-sectional cohort of 1,230 adolescents (age mean ± SD: 17.1 ± 1.9 years) from South India.

Results

The variant at the FTO locus was found to be associated with waist-hip ratio (WHR) but not with overall obesity in this population. No significant association was observed for obesity-traits and Mc4R variant rs17782313.

Conclusion

The common variant of FTO (rs9939609) is associated with body fat distribution during early growth in Indian adolescents and may predispose to obesity and metabolic consequences in adulthood.

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