Reduced prevalence of obesity in children with primary fructose malabsorption: a multicentre, retrospective cohort study
Article first published online: 29 APR 2013
© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity
Special Issue: Dietary sugars and obesity in children
Volume 8, Issue 4, pages 255–258, August 2013
How to Cite
Disse, S. C., Buelow, A., Boedeker, R.-H., Keller, K.-M., Kim-Berger, H.-S., Wudy, S. A. and Zimmer, K.-P. (2013), Reduced prevalence of obesity in children with primary fructose malabsorption: a multicentre, retrospective cohort study. Pediatric Obesity, 8: 255–258. doi: 10.1111/j.2047-6310.2013.00163.x
- Issue published online: 15 JUL 2013
- Article first published online: 29 APR 2013
- Manuscript Accepted: 25 FEB 2013
- Manuscript Revised: 31 JAN 2013
- Manuscript Received: 10 DEC 2012
- Justus-Liebig University Giessen
- Childhood obesity;
- fructose malabsorption;
- multicentre study
Studies in animals and in man have demonstrated that excessive consumption of fructose can cause all components of the metabolic syndrome.
To investigate the impact of a condition resulting in decreased absorption of fructose, on obesity.
In a multicentre study, we analyzed a cohort of paediatric patients with suspected primary fructose malabsorption (FM). Patients with chronic intestinal diseases were excluded. The final cohort comprised 628 patients.
302 patients were diagnosed with primary FM (48.1%). The proportion of obese patients was lower among FM patients, compared to non-FM patients (2.3 vs. 6.1%, P = 0.029). Logistic regression analysis with inclusion of various covariates showed that FM was negatively associated with obesity (OR 0.35, 95% CI [0.13; 0.97]). We discuss several mechanisms involving the metabolic, endocrine and gastrointestinal system.
Our data indicate that primary FM is negatively associated with childhood obesity.