Trial Registry Name: Clinicaltrials.gov Protocol Registration System
Compensatory responses to insulin resistance in obese African-American and Latina girls
Article first published online: 2 JUL 2013
© 2013 The Authors. Pediatric Obesity © 2013 International Association for the Study of Obesity
Volume 8, Issue 6, pages e68–e73, December 2013
How to Cite
Hasson, R. E., Adam, T. C., Davis, J. N., Watanabe, R. M. and Goran, M. I. (2013), Compensatory responses to insulin resistance in obese African-American and Latina girls. Pediatric Obesity, 8: e68–e73. doi: 10.1111/j.2047-6310.2013.00184.x
Registry Identification Number:
Unique Protocol ID: 5R01HD33064-13, Clinical Trials ID: NCT00697580
Unique Protocol ID: 195-1642394A1
- Issue published online: 21 NOV 2013
- Article first published online: 2 JUL 2013
- Manuscript Accepted: 15 MAY 2013
- Manuscript Revised: 22 APR 2013
- Manuscript Received: 12 NOV 2012
- USC Transdisciplinary Research on Energetics and Cancer. Grant Number: U54 CA 116848
- National Institute of Child Health and Human Development. Grant Number: RO1 HD/HL 33064
- Dr. Robert C and Veronica Atkins Foundation
- National Cancer Institute. Grant Number: T32 CA 09492
- hepatic insulin extraction;
- pancreatic insulin secretion
Insulin responses to oral and intravenous glucose markedly differ by ethnicity. This study examined whether ethnic differences in pancreatic insulin secretion, hepatic insulin extraction and clearance explain these disparate findings in 35 obese African–American and 41 Latina girls (Tanner Stages: IV–V; ages: 14–18; body mass index percentile: 85.9–99.8%).
Pancreatic insulin secretion, hepatic insulin extraction and clearance were estimated by C-peptide and insulin modeling during an oral glucose tolerance test. Insulin sensitivity (SI), acute insulin response to glucose (AIRG) and disposition index were derived from a frequently sampled intravenous glucose tolerance test.
Compared to Latinas, obese African–American adolescents had lower pancreatic insulin secretion (21.3%; P < 0.01), glucose incremental area under the curve (IAUC) (41.7%, P = 0.02), C-peptide IAUC (25.1%, P < 0.01) and SI (33.7%; P < 0.01). There were no ethnic differences in hepatic insulin extraction and clearance (P's > 0.05).
Compensatory mechanisms to insulin resistance do not appear to explain the ethnic differences in insulin responses to oral and intravenous glucose in obese African–American and Latina girls.